Dr Andrew Overall
Senior Lecturer
contact:
Pharmacy and Biomolecular Sciences
Moulsecoomb
Brighton
BN2 4GJ
Telephone: +44 (0)1273 642099
Email: A.D.J.Overall@brighton.ac.uk
Research Interests
- Looking at the genetics of populations to study the fitness consequences of inbreeding and population subdivision
- Using microsatellites to infer population dynamics and as phenotypic markers. Current studies include:
- The consequences of consanguinity and population substructure to the genetic health of British Asian communities.
- The molecular ecology of water vole populations of the South East of England/Browm hyena & jackel populations of South Africa.
- The genetic basis of age-related phenotypic decline in a model organism Lymnaea stagnalis.
Recent Publications
Overall ADJ. 2009. The influence of the Wahlund effect on the consanguinity hypothesis: Consequences for recessive disease incidence in a socially structured Pakistani population. Human Heredity 67, 140-144.
Golding BJD, Overall ADJ, Brown G and Gard PR. 2010. Strain differences in the effects of angiotensin IV on mouse cognition. European Journal of Pharmacology 641, 154-159.
Golding B, Overall A, Gard P. (2008) The role of IRAP in the effect of angiotensin IV on cognition in the mouse. Fundamental & Clinical Pharmacology 22, 103.
Overall ADJ. 2008. Recessive disorders: Consanguinity and substructure in British Pakistani communities. In: Viktor T. Koven (Ed), Population Genetics Research Progress (Chapter 3, pp 85-122). Nova Science Publishers Inc, USA.
SCOTT, DAWN and OVERALL, ANDREW (2012) The Eurasian water shrew: an unsuitable candidate species for a vertebrate bio-indicator of aquatic pollution Journal of Zoology, 286 (1). pp. 30-37. ISSN 0952-8369
Ogilvie, L.A., Overall, A.D.J. and Jones, B.V. (2012) The human-mirobiome co-evolutionary continuum In: Ogilvie, L.A. and Hirsch, P., eds. Microbial ecological theory: current perspectives. Caister Academic Press . ISBN 9781908230096
Saab , Y.B., Gard , P.R. and Overall, A.D.J. (2011) The association of hypertension with renin-angiotensin system gene polymorphisms in the Lebanese population Journal of the Renin-Angiotensin-Aldosterone System, 12 (7). pp. 588-594. ISSN 1470-3203
Overall, A.D.J. (2011) The effect of population stratification on the frequency of compound heterozygosity Genetica, 139 (3). pp. 403-409. ISSN 0016-6707
OVERALL, ANDREW (2011) The effect of substructure on the frequency of compound heterozygosity Genetica . ISSN 0016-6707 (In Press)
GARD, PAUL and OVERALL, ANDREW (2011) Strain differences and the role of AT1 receptor expression in anxiety International Journal of Molecular Epidemiology and Genetics, IJMEG, 2 (1). pp. 51-55. ISSN 1948-1756
Golding, Bruno J. D., Overall, A.D.J., Brown, Graham and Gard, P.R. (2010) Strain differences in the effects of Angiotensin IV on mouse cognition European Journal of Pharmacology, 641 (2-3). pp. 154-159. ISSN 0014-2999
Overall, A.D.J. (2009) The influence of the Wahlund effect on the consanguinity hypothesis: consequences for recessive disease incidence in a socially structured Pakistani population Human Heredity, 67 (2). pp. 140-144. ISSN 0001-5652
Golding, B., Overall, A.D.J. and Gard, P.R. (2008) The role of IRAP in the effect of angiotensin IV on cognition in the mouse Wiley-Blackwell, UK.
Overall, A.D.J. (2008) Recessive disorders: Consanguinity and substructure in British Pakistani communities In: Koven, Viktor T., ed. Population Genetics Research Progress. Nova Science Publishers Inc, USA, pp. 85-122.
Saab, Y.B, Gard, P.R and Overall, A.D.J (2007) The geographic distribution of the ACE II genotype: a novel finding Genetics Research, 89 (4). pp. 259-267. ISSN 0016-6723
Overall, A.D.J., Byrne, K.A., Pilkington, J.G. and Pemberton, J.M. (2005) Heterozygosity, inbreeding and neonatal traits in Soay sheep on St Kilda Molecular ecology, 14 (11). pp. 3383-3393. ISSN 1365-294X
Wilson, A.J., Coltman, D.W., Pemberton, J.M., Overall, A.D.J., Byrne, K.A. and Kruuk, L.E.B. (2005) Maternal genetic effects set the potential for evolution in a free-living vertebrate population Journal of evolutionary biology, 18 (2). pp. 405-414. ISSN 1420-9101
Wilson, A.J., Pilkington, J.G., Pemberton, J.M., Coltman, D.W., Overall, A.D.J., Byrne, K.A. and Kruuk, L.E.B. (2005) Selection on mothers and offspring: Whose phenotype is it and does it matter? Evolution, 59 (2). pp. 451-463. ISSN 1558-5646
Ayres, K.L. and Overall, A.D.J. (2004) Api-calc 1.0: a computer program for calculating the average probability of identity allowing for substructure, inbreeding and the presence of close relatives Molecular ecology notes, 4 (2). pp. 315-318. ISSN 1471-8278
Overall, A.D.J., Ahmad, M., Thomas, M.G. and Nichols, R.A. (2003) An analysis of consanguinity and social structure within the UK asian population using microsatellite data Annals of human genetics, 67 (6). pp. 525-537. ISSN 0003-4800
Miller, N.J., Birley, A.J., Overall, A.D.J. and Tatchell, G.M. (2003) Population genetic structure of the lettuce root aphid, Pemphigus bursarius (L.), in relation to geographic distance, gene flow and host plant usage Heredity, 91 (3). pp. 217-223. ISSN 0018-067X
Overall, A.D.J., Ahmad, M. and Nichols, R.A. (2002) The effect of reproductive compensation on recessive disorders within consanguineous human populations Heredity, 88 (6). pp. 474-479. ISSN 0018-067X
Overall, A.D.J. and Nichols, R.A. (2001) A method for distinguishing consanguinity and population substructure using multilocus genotype data Molecular biology and evolution, 18 . pp. 2048-2056. ISSN 0737-4038
