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Prof Anthony Metcalfe

Prof in Burns and Wound Healing Research

contact:
Pharmacy and Biomolecular Sciences
Moulsecoomb
Brighton
BN2 4GJ

Email: A.Metcalfe@brighton.ac.uk

Research Interests:

  • Burns
  • Wound Healing
  • Tissue repair and regeneration
  • Fibrosis and scarring
  • Adhesions
  • Skin substitutes
  • Nerve, tendon and ocular regeneration,
  • Angiogenesis and neovascularization
  • Embryology
  • Stem cells
  • Mammary gland biology
  • Cancer
  • Apoptosis

 

Publications:

Kieran I, Knock A, Bush J, So K, Metcalfe AD, Hobson R, Mason T, O'Kane S, Ferguson MW. (2013). Interleukin-10 reduces scar formation in both animal and human cutaneous wounds: Results of two preclinical and phase II randomized control studies. Wound Repair Regen; 21(3):428-36. ISSN: 1524-475X

Buckley G, Wong J, Metcalfe AD, Ferguson MW. (2012) Denervation affects regenerative responses in MRL/MpJ and repair in C57BL/6 ear wounds. J Anat 220(1):3-12.

Metcalfe AD, Occleston NL, Boanas A, Burgoyne NJ, Nield K, O'Kane S, Ferguson MW. (2011). The discovery and development of new therapeutic treatments for the improvement of scarring. Chapter 4, In “Advanced Wound Repair Therapies”, Ed D.Farrer, Woodhead Publishing Limited, Cambridge.

Metcalfe, AD, and Ferguson, MWJ. (2011). Regeneration of Mammalian Skin.  In Encyclopaedia of Life Sciences. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0001109.pub2]

Ngeow WC, Atkins S, Morgan CR, Metcalfe AD, Boissonade FM, Loescher AR, Robinson PP (2011). A comparison between the effects of three potential scar-reducing agents applied at a site of sciatic nerve repair. Neuroscience 181; 271-277.

Ngeow WC, Atkins S, Morgan CR, Metcalfe AD, Boissonade FM, Loescher AR, Robinson PP (2011). The effect of Mannose-6-Phosphate on recovery after sciatic nerve repair. Brain Res;1394:40-8

Ngeow WC, Atkins S, Morgan CR, Metcalfe AD, Boissonade FM, Loescher AR, Robinson PP (2011). Histomorphometric changes in repaired mouse sciatic nerves are unaffected by the application of a scar reducing agent. J Anat 219(5):638-45.

So K, McGrouther DA, Bush JA, Durani P, Taylor L, Skotny G,  Mason T, Metcalfe AD, O'Kane S, Ferguson MWJ (2011). Avotermin for Scar Improvement following Scar Revision Surgery: A Randomized, Double-Blind, Within-Patient, Placebo-Controlled, Phase II Clinical Trial. Plast Recon Surg 128(1); 163-172.

Buckley G, Metcalfe AD, Ferguson MW (2011). Peripheral nerve regeneration in the MRL/MpJ ear wound model. J Anat. 218(2):163-72.

Occleston NL, Metcalfe AD, Boanas A, Burgoyne NJ, Nield K, O'Kane S, Ferguson MW. (2010). Therapeutic improvement of scarring: mechanisms of scarless and scar-forming healing and approaches to the discovery of new treatments. Dermatol Res Pract. pii: 405262.

Metcalfe AD and Ferguson MW (2008). Skin stem and progenitor cells: using regeneration as a tissue-engineering strategy. Cell Mol Life Sci 65(1):24-32.

Kimber SJ, Sneddon SF, Bloor DJ, El-Bareg AM, Hawkhead JA, Metcalfe AD, Houghton FD, Leese HJ, Rutherford A, Lieberman BA, Brison DR (2008). Expression of genes involved in early cell fate decisions in human embryos and their regulation by growth factors. Reproduction; 135(5):635-47.

Metcalfe AD, Ferguson MW. (2007) Bioengineering skin using mechanisms of regeneration and repair. Biomaterials 28(34):5100-13.

Metcalfe AD and Ferguson MW (2007). Tissue Engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration. Journal of The Royal Society Interface 4(14):413-37.

Metcalfe AD, Willis H, Beare A, Ferguson MW (2006). Characterizing regeneration in the vertebrate ear. J Anat. 209(4):439-46.

Beare AH, Metcalfe AD, Ferguson MW (2006) Location of injury influences the mechanisms of both regeneration and repair within the MRL/MpJ mouse. J Anat; 209(4):547-59.

Metcalfe AD and Ferguson MW (2005). Harnessing Wound Healing and Regeneration for Tissue Engineering. Biochem Soc Trans;33(Pt 2):413-7.

Metcalfe AD, Bartlett JP, Beare, AH, Ferguson MW (2005). Characterising Mechanisms of Regeneration for Future Applications in Tissue Engineering.  European Cells and Materials 10 (2):16-17.

Buckley, G, Metcalfe, AD, Ferguson MWJ (2005). Characterisation of The Regenerative Ability of The MRL/MPJ Mouse in Order to Re-Innervate and Promote Scar-Free Healing in Engineered Skin Equivalents. European Cells and Materials 10 (2):38-39.

Brison DR, Metcalfe AD, Bloor DJ, Hunter HR, Brady G, Kimber SJ (2004). Analysis of apoptosis in the preimplantation embryo. A Laboratory Guide to the Mammalian Embryo (Eds Gardner DK, Lane M, Watson AJ). Oxford University Press. eScholarID:3d880

Metcalfe AD, Hunter HR, Bloor DJ, Lieberman BA, Picton HM, Leese HJ, Kimber SJ and Brison DJ.  (2004). Expression of 11 members of the BCL2 family of apoptosis regulatory molecules during human preimplantation embryo development and fragmentation. Molecular Rep and Dev, 68(1):35-50.

Metcalfe AD, Bloor DJ, Lieberman BA, Kimber SJ and Brison DR. (2003). Amplification of representative cDNA pools from single human oocytes and pronucleate embryos. Mol Reprod Dev. 65(1):1-8.

Rajnoch C, Ferguson S, Metcalfe AD, Herrick SE, Willis HS and Ferguson MW. (2003). Regeneration of the ear following wounding in different mouse strains is dependent on the severity of wound trauma. Dev Dyn. 226(2):388-97.

Valentijn AJ, Metcalfe AD, Kott J, Streuli CH and Gilmore AP. (2003). Spatial and temporal changes in Bax subcellular localization during anoikis. J Cell Biol.;162(4):599-612.

Bloor DJ, Metcalfe AD, Rutherford A, Brison DR, Kimber SJ. (2002). Expression of cell adhesion molecules during human preimplantation embryo development. Mol Hum Reprod. 8(3):237-45.

Gilmore AP, Metcalfe AD, Romer LH and Streuli CH (2000). Integrin-mediated Survival Signals Regulate the Apoptotic Function of Bax through Its Conformation and Subcellular Localization. J Cell Biol. 149, (2) 431-445.

Metcalfe AD, Gilmore A, Klinowska T, Oliver J, Valentijn, AJ, Brown R, Ross A, Macgregor G, Hickman JA, Streuli CH (1999). Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland. J.Cell Sci.112: 1771-1783.

Taylor MF, Woolveridge I, Metcalfe AD, Streuli CH, Hickman JA, Morris ID. (1998). Leydig cell apoptosis in the rat testes after administration of the cytotoxin ethane dimethanesulphonate: role of the Bcl-2 family members. J. Endocrinol. 157(2):317-26.

Metcalfe AD, Streuli CH (1997). Epithelial apoptosis. Bioessays 19(8) 711-720.

Streuli CH, Dive C, Hickman JA, Farelly NJ, Metcalfe AD (1997) Control of apoptosis in breast epitheium. Endocrine-Related Cancer 4:45-53.

Metcalfe AD, Hickman JA, Streuli CH (1996). Programmed cell death and the mammary gland--the involvement of the Bcl-2 family members in the control of epithelial apoptosis. Biochem Soc Trans. 24(3):347S.

Pullan S, Wilson J, Metcalfe AD, Edwards, GM, Goberdhan N, Tilly J, Hickman JA, Dive C & Streuli CH. (1996). Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium. J Cell Sci. 109 (Pt 3):631-42.

Hayashi S, Hirose S, Metcalfe AD, Shirras AD (1993). Control of imaginal cell development by the escargot gene of Drosophila. Development 118(1):105-15.