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Dr Ananth Pannala

Principal Lecturer

contact:
Pharmacy and Biomolecular Sciences
Moulsecoomb
Brighton
BN2 4GJ

Telephone: +44 (0)1273 642109

Email: A.S.V.Pannala@brighton.ac.uk

Research Interests

  • Interaction of free radicals with drug molecules and their effect on the mechanism of action.
  • Drug delivery, absorption, metabolism and excretion of active compounds.
  • Effect of natural compounds in health and disease.
  • Drug product development of novel chemical entities.

Research Publications

  • Traynor, MJ, Pannala, AS, Beck, P, Martin, GP and Brown, MB. Influence of alcohol on the release of Tramadol from twenty-four hour controlled release formulations during in vitro dissolution experiments. (2008) Drug Development and Industrial Pharmacy. 34(8), 885-889.
  • Pannala, AS, Mani, AR, Rice-Evans, CA and Moore, KP. pH-dependent nitration of parahydroxyphenylacetic acid in the stomach. (2006) Free Radicals in Biology and Medicine, 41, 896-901.
  • Lee, SY, Munerol, B, Pollard, S, Youdim, KA, Pannala, AS, Kuhnle, GG, Debnam, ES, Rice-Evans, C and Spencer, JP. The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth. (2006), Free Radicals in Biology and Medicine, 40, 323-334.
  • Hughes, RA, Umapathi, T, Gray, IA, Gregson, NA, Noori, M, Pannala, AS, Proteggente, A and Swan, AV. A controlled investigation of the cause of chronic idiopathic axonal polyneuropathy.(2004) Brain,127, 1723-1730.
  • Chan, TS, Galati, G, Pannala, AS, Rice-Evans, C and O’Brien, PJ. Simultaneous detection of the antioxidant and pro-oxidant activity of dietary polyphenolics in a peroxidase system. (2003) Free Radical Research, 37, 787-794.
  • Mani, AR, Pannala, AS, Orie, NN, Ollosson, R, Harry, D, Rice-Evans, CA and Moore KP. Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine. (2003) Biochemical Journal, 374, 521-527.
  • Pannala, AS, Mani AR, Spencer, JP, Skinner, V, Bruckdorfer, KR, Moore, KP and Rice-Evans, CA. The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans.(2003) Free Radicals Biology and Medicine, 34, 576-584.
  • Pannala, AS, Bruckdorfer, KR, and Rice-Evans, CA. Smoking has no effect on the amino acid composition of apolipoprotein B100 of LDL while directly influencing the antioxidant status. (2002) Biochemical and Biophysical Research Communications, 292, 175-183.
  • Proteggente, A, Pannala, AS, Paganga, G, van Buren, L, Wagner, E, Wiseman, S, van de Put, F, Dacombe, C, and Rice-Evans, CA. The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition. (2002) Free Radical Research, 36, 217-233.
  • Rechner, A, Pannala, AS, and Rice-Evans, CA. Caffeic acid derivatives in artichoke extract are metabolized to phenolic acids in vivo. (2001) Free Radical Research, 35, 195-202.
  • Pannala, AS, Chan, T, O'Brien, PJ, and Rice-Evans, CA. Flavonoid B-ring chemistry and antioxidant activity: Fast reaction kinetics. (2001) Biochemical and Biophysical Research Communications, 282, 1161-1168
  •  Pannala, AS, and Rice-Evans, CA. Rapid screening method for relative antioxidant activities of flavonoids and phenolics. (2000) Methods in Enzymology, 335, 266-272.
  • Spencer, JPE, Chaudry, F, Pannala, AS, Srai, KS, Debnam, E, and Rice-Evans, C. Decomposition of cocoa procyanidins in the gastric milieu. (2000) Biochemical and Biophysical Research Communications, 272, 236-241.
  • Re, R, Yang, M, Pellegrini, N, Pannala, AS, Proteggente, A, and Rice-Evans, CA. Antioxidant activity applying an improved ABTS radical cation decolorization assay. (1999) Free Radical Biology & Medicine, 26, 1231-1237.
  • Pannala, AS, Singh, S, and Rice-Evans, CA. Flavonoids as peroxynitrite scavengers in vitro. (1999) Methods in Enzymology, 299, 207-235
  • Pannala, AS, Singh, S, and Rice-Evans, CA. Interaction of carotenoids and tocopherols with peroxynitrite. (1999) Methods in Enzymology, 301, 319-332.
  • Kayyali, R, Pannala, AS, Khodr, H, and Hider, RC. Comparative radical scavenging ability of bidentate iron (III) chelators. (1998) Biochemical Pharmacology, 55, 1327-1332.
  • Pannala, AS, Razaq, R, Halliwell, B, Singh, S, and Rice-Evans, CA. Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation? (1998) Free Radical Biology & Medicine, 24, 594-606.
  • Pannala, AS, Rice-Evans, CA, Sampson, J, and Singh, S. Interaction of peroxynitrite with carotenoids and tocopherols within low-density lipoprotein. (1998) FEBS Letters, 423, 297-301.
  • Pannala, AS, Rice-Evans, CA, Halliwell, B, and Singh, S. Inhibition of peroxynitrite-mediated tyrosine nitration by catechin polyphenols. (1997) Biochemical and Biophysical Research Communications, 232, 164-168.