Skip to content

Dr Bhavik Patel

Senior Lecturer

contact:
Pharmacy and Biomolecular Sciences
Moulsecoomb
Brighton
BN2 4GJ

Telephone: +44 (0)1273 642418

Email: B.A.Patel@brighton.ac.uk

Research Interests

The B Sensor Group research interests are on the interface between the physiology of cellular signalling mechanisms and novel electroanalytical techniques. The research activities currently being pursued are shown below:

Chemical Sensors

We are interested in the development of various chemical sensors that allow for the stable and reproducible monitoring of important biomolecules. Specifically we are interested in the investigation of novel carbon based materials as electrodes for long-term electrochemical recordings. Alongside our collaborators we have utilised boron-doped diamond microelectrodes for stable monitoring of serotonin. We have also developed microelectrode arrays, needle-type sensors and biosensors for the detection of a host of important biological chemicals. To date we have fabricated sensors and / or devices for the detection of serotonin, nitric oxide and ATP.

Understanding Signalling Mechanism in the Gastrointestinal Tract

The gastrointestinal tract is responsible for a wide range of functions: motility, secretion, digestion, adsorption and regulation. These processes require a fine tuned enteric nervous system (ENS), which is often known as the second brain in the body. We are interested in understanding the spatial and temporal dynamics behind the signalling mechanism and how it relates to the variety of GI functions. We are fusing novel analytical approaches with traditional functional assays to gain more insight in the physiology of the digestive system. As part of this work, alongside our collaborators in Michigan State University, we have looked at alterations in intestinal signalling mechanism during development. 

Functional Gastrointestinal Disorders

One in four people have some activity limitation due to a functional gastrointestinal disorder. These account for 40 % of gastrointestinal problems seen by doctors and therapists. Examples of these disorders include dyspepsia, gastroesophageal reflux disease (GERD), chronic constipation and irritable bowel syndrome (IBS).  Between 10 -20 % of the UK population is diagnosed for IBS and this number is increasing, particular in women. We are looking alterations in the serotonin signaling mechanism during the onset of functional gastrointestinal disorders in the lower bowel. Serotonin is a key signaling molecule in the digestive tract and is well known to influence motility. In the upper bowel, we are looking at simultaneous measurements of histamine and pH to study gastric disorders. These studies are in collaboration with the Royal London and Brighton Sussex University Hospitals; where we aim to gain better insight into the changes occurring in signaling during such conditions.

Scholarly Activities

Awards

GlaxoSmithKline Award for highest overall degree mark (2002)
EPSRC LifeSciences section award for poster presentation (2003)
JSPS Postdoctoral Fellowship for scientific research in Japan (2004)
Best Poster Presentation, CIM Meeting (2007)
Staff Award Department of Bioengineering, Imperial College London for research supervision (2008)

Society Membership

Member of the Royal Society of Chemistry (RSC)
Member of the American Chemical Society (ACS)
Member of British (London) Chapter of the Society for Neuroscience (SfN)
Member of the International Society of Electrochemistry (ISE)
Member of the Society of Electroanalytical Chemistry (SEAC)

Grants and Funding

2011-2012 - Royal Society Research Grant PI £13,635

2011-2012 - UoB Sabbatical Award PI £15,906

2011-2013 - BBSRC Interational Partnership Award Co-I £26,439

2010-2015- CHIR Project Grant, Canada Co-I $840,875

2010-2013 - BBSRC Ageing Bladder and Bowel initiative, Co-I £356,000

2006-2009 - ESPRC LSI Overseas Research Fellowship, PI £139,526

 

Collaborations

Recent Invited Lecturers

  • unravelling serotonin signalling mechanisms in the enteric nervous system, at Pittcon 2011 Atlanta, USA. Mar 2011
  • Novel methods to study gastrointestinal disorders: From bench to bedside, Digestive Diseases Centre Academic Day, Brighton Sussex University Hospital, Apr 2010
  • Analytical methods to study the role of neurotransmission within the gastrointestinal tract, Department of Chemistry, University of Gothenburg, Apr 2009
  • Electroanalytical methods to understand changes in uptake rate during steady-state neurotransmission, SEAC Organised Session, Pittcon, Chicago, USA, Mar 2009
  • Theoretical modelling to understand the neurotransmission mechanism in the gastrointestinal tract; Automation in Anaesthesia, IEEE Engineering in Medicine and Biology, Vancouver, Canada, Aug 2008
  • Analytical methods used to study the role of neurotransmission within the gastrointestinal tract,School of Medicine, University of Southampton, May 2008
  • Novel analytical methods used to study neurotransmission within the gastrointestinal tract,Department of Physiology and Biophysics, University of Calgary, Canada, Apr 2008
  • Current Engineering Challenges in Biology: Understanding the activity of the gastrointestinal tract; Division of Engineering, Kings College London, Feb 2008
  • In vitro monitoring of neurotransmitters that influence the activity of the gastrointestinal tract, Department of Bioengineering, Imperial College London, Jan 2008
  • In vitro monitoring of neurotransmitter release from the gastrointestinal tract: A means of understanding motility, Department of Chemistry, Southampton University, Dec 2007

Book Chapters

B.A. Patel, C.A. Anastassiou and D. O’Hare, Biosensor design and Interfacing, 2006, Body Sensors Networks, Ed: G-Z. Yang, Springer, New York, 41 – 82

S.V. Mikhalovsky, B.A. Patel, K.J. Rutt, V.I. Padalko, V.V. Torov, V.M. Bogatyrev and V.M. Gun’ko, Structural and Adsorption Characteristics of Porous Industrial Diamond, 2005, Innovative Superhard Materials and Sustainable Coatings for Advanced Manufacturing, Eds: J. Lee and N. Novikov,  NATO Science Series: II. Mathematics, Physics and Chemistry – Vol. 2000, Springer, Amsterdam, 169 – 182 

Research Publications

Number of items: 35.

Dube, Lorraine E., PATEL, BHAVIK, FAGAN-MURPHY, AIDAN, Kothur, Raghu R. and CRAGG, PETER (2013) Detection of clinically important cations by a pillar[5]arene-modified electrochemical sensor Chemical Sensors, 3 (18). ISSN 1008-2298

PATEL, BHAVIK, YEOMAN, MARK, Morgan, L.D. and Baker, H. (2012) Chromatographic assay to study the activity of multiple enzymes involved in the synthesis and metabolism of dopamine and serotonin Analyst, 137 (6). ISSN 0003-2654

MacEachern, S., Patel, B.A., McKay, D.M. and Sharkey, K.A. (2011) Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus Journal of Physiology, 589 . pp. 3333-3348. ISSN 0022-3751

Patel, B.A., Rogers, M., Wieder, T., O'Hare, D. and Boutelle, M.G. (2011) ATP microelectrode biosensor for stable long-term in vitro monitoring from gastrointestinal tissue Biosensors and Bioelectronics, 26 (6). pp. 2890-2896. ISSN 0956-5663

Patel, B.A. (2011) Electroanalytical approaches to study signaling mechanisms in the gastrointestinal tract Neurogastroenterology and Motility, 23 (7). pp. 595-605. ISSN 1350-1925

Patel, B.A., Arundell, M., Parker, K.H., Yeoman, M.S. and O'Hare, D. (2010) Microelectrode investigation of neuroneal ageing from a single identified neurone Physical Chemistry Chemical Physics, 12 (34). pp. 10065-10072. ISSN 1463-9076

Marcelli, G. and Patel, B.A. (2010) Understanding changes in uptake and release of serotonin from gastrointestinal tissue using a novel electroanalytical approach Analyst, 135 (9). pp. 2340-2347. ISSN 0003-2654

Singh, Y.S., Sawarynski, L.E., Michael, H.M., Ferrell, R.E., Murphy-Corb, M.A., Swain, G.M., Patel, B.A. and Andrews, A.M. (2010) Serotonin uptake associated with the short allele of the rhesus 5HTTLPR is reduced in lymphocytes during adulthood ACS Chemical Neuroscience, 1 (1). pp. 49-64. ISSN 1948-7193

Singh, Y.S., Sawarynski, L.E., Michael, H.M., Ferrell, R.E., Murphy-Corb, M.A., Swain, G.M., Patel, B.A. and Andrews, A.M. (2010) Boron-doped diamond microelectrodes reveal reduced Sserotonin uptake rates in lymphocytes from adult rhesus monkeys carrying the short allele of the 5-HTTLPR ACS Chemical Neuroscience, 1 (1). pp. 49-64. ISSN 1948-7193

Trouillon, R., Combs, Z., Patel, B.A. and O'Hare, D. (2010) Electrochemical study of the intracellular transduction of vascular endothelial growth factor induced nitric oxide synthase activity using a multi-channel biocompatible microelectrode array BBA - Biochimica et Biophysica Acta, 1800 (9). pp. 929-936. ISSN 0006-3002

Lwin, A. and Patel, B.A. (2010) High performance liquid chromatography method for the detection of released purinergic and biogenic amine signalling molecules from in vitro ileum tissue Journal of Separation Science, 31 (11). pp. 1538-1545. ISSN 1615-9306

Patel, B.A., Dai, X., Burda, J.E., Zhao, H., Swain, G.M., Galligan, J.J. and Bian, X. (2010) Inhibitory neuromuscular transmission to ileal longitudinal muscle predominates in neonatal guinea pigs Neurogastroenterology & Motility, 22 (8). 909-e237. ISSN 1350-1925

Bitziou, E., O'Hare, D. and Patel, B.A. (2010) Spatial changes in acid secretion from isolated stomach tissue using a pH-histamine sensing microarray Analyst, 135 (3). pp. 482-487. ISSN 0003-2654

Seo, J., Cho, S., Lim, H., Park, J., Leow, P.L., Patel, B.A., Park, J. and O'Hare, D. (2009) Development of embedded metal lines in a plastic electrochemical microfluidic device by blanket mould imprinting Lab On A Chip, 9 (15). pp. 2238-2244. ISSN 1473-0197

Trouillon, R., Cheung, C., Patel, B.A. and O'Hare, D. (2009) Comparative study of poly(styrenesulfonate)/poly(L0lysine) and fibronectin as biofouling-preventing layers in dissolved oxygen electrochemical measurements Analyst, 134 (4). pp. 784-793. ISSN 0003-2654

Troullion, R., Combs, Z., Patel, B.A. and O'Hare, D. (2009) Comparative study of the effect of various electrode membranes on biofouling and electrochemical measurements Electrochemistry Communications, 11 (7). pp. 1409-1413. ISSN 1388-2481

Chau, R.M.W. and Patel, B.A. (2009) Determination of serotonin, melatonin and metabolites in gastrointestinal tissue using high-performance liquid chromatography with electrochemical detection Biomedical Chromatography, 23 (2). pp. 175-181. ISSN 0269-3879

Seo, J., Cho, S., Lim, H., Park, J., Leow, P.L., Patel, B.A. and O'Hare, D. (2009) Development of inlaid electrodes for whole column electrochemical detection Lab on a Chip, 9 (15). pp. 2238-2244. ISSN 1473-0197

Bitziou, E., Patel, B.A. and O'Hare, D. (2008) Simultaneous detection of pH changes and histamine release from oxyntic glands in isolated stomach Analytical Chemistry, 80 (22). pp. 8733-8740. ISSN 0003-2700

Patel, B.A., Galligan, J.J., Swain, G.M. and Bian, X. (2008) Detection of nitric oxide released from the myenteric plexus of the guinea pig ileum Neurogastroenterology and Motility, 20 (11). pp. 1243-1250. ISSN 1350-1925

Yeoman, M.S, Patel, B.A, Arundell, M, Parker, K and O'Hare, D (2008) Synapse-specific changes in serotonin signalling contribute to age-related changes in the feeding behaviour of the pond snail, Lymnaea Journal of Neurochemistry, 106 (4). pp. 1699-1709. ISSN 0022-3042

Patel, B.A. (2008) Continuous amperometric detection of co-released serotonin and melatonin from the mucosa in the ileum Analyst, 133 . pp. 516-524. ISSN 0003-2654

Patel, B.A. (2008) Continuous amperometric detection of co-released serotonin and melatonin from the mucosa in the ileum Analyst, 133 (4). pp. 516-524. ISSN 0003-2654

Park, J., Quaiserova-Mocko, V., Patel, B.A., Novotony, M., Lui, A., Bain, X., Galligan, J.J. and Swain, G.M. (2008) Diamond microelectrodes for in vitro electroanalytical measurements: current status and remaining challenges Analyst, 133 (1). pp. 17-24. ISSN 0003-2654

Patel, B.A., Galligan, J.J., Swain, G.M. and Bian, X. (2008) Electrochemical monitoring of nitric oxide released by myenteric neurons of the guinea pig ileum Neurogastroenterology & Motility, 20 (11). pp. 1243-1250. ISSN 1350-1925

Patel, B.A., Arundell, M., Quek, R.G.W., Harvey, S.L., Ellis, I.R., Florence, M.M., Cass, A., Schor, A.M. and O'Hare, D. (2008) Individually addressable plug and play microelectrode arrays for bioanalysis Analytical and Bioanalytical Chemistry, 390 (5). pp. 1618-1642. ISSN 1618-2642

Bitziuo, E., O'Hare, D. and Patel, B.A. (2008) Simultaneous detection of pH changes and histamine release from oxyntic glands in isolated stomach Analytical Chemistry, 80 (22). pp. 1243-1250. ISSN 0003-2700

Bain, X., Patel, B.A., Dai, X., Galligan, J.J. and Swain, G.M. (2007) High mucosal serotonin availability in neonatal guinea pig ileum is associated with a low serotonin transporter expression Gastroenterology, 132 (7). pp. 2438-2447.

Patel, B.A., Bian, X., Quaiserova-Mocko, V., Galligan, J.J. and Swain, G.M. (2007) In vitro continuous amperometric monitoring of 5-hydroxytryptamine release from enterochromaffinn cells of the guinea pig ileum Analyst, 132 . pp. 41-47. ISSN 0003-2654

Patel, B.A, Arundell, M, Parker, K.H, Yeoman, M.S and O'Hare, D (2006) Detection of nitric oxide release from single neurons in the pond snail, Lymnaea stagnalis Analytical Chemistry, 78 (22). pp. 7643-7648. ISSN 0003-2700

Anastassiou, C.A, Patel, B.A, Arundell, M, Yeoman, M.S, Parker, K.H and O'Hare, D (2006) Subsecond voltametric separation between dopamine and serotonin in the presence of ascorbate Analytical Chemistry, 78 (19). pp. 6990-6998. ISSN 0032-2700

Patel, B.A., Arundell, M., Allen, M.C., Gard, P.R, Parker, K. and Yeoman, M.S. (2006) Changes in the properties of the modulatory cerebral giant cells contribute to aging in the feeding system of Lymnaea Neurobiology of Aging, 27 (12). pp. 1892-1901.

Patel, B.A., Arundell, M., Parker, K.H., Yeoman, M.S. and O'Hare, D. (2005) Simple and rapid determination of serotonin and catecholamines in biological tissue using high-performance liquid chromatography with electrochemical detection Journal of chromatography B, 818 (2). pp. 269-276. ISSN 1570-0232

Patel, B.A., Arundell, M., Parker, K., Yeoman, M.S and O'Hare, D. (2005) Decreases in the serotonin content of a pair of identified neurones can explain the effect of p-chlorophenylanaline on the feeding behaviour of the pond snail, lymnaea stagnalis Current Separations, 21 (2). pp. 53-58.

Arundell, M. and Patel, B.A. (2004) Hilbert transformation of voltammetric data Electrochemical Communications, 6 (4). pp. 366-372.

This list was generated on Tue Jun 11 07:04:07 2013 BST.