Dr Claire Marriott
Senior Lecturer
contact:
Pharmacy and Biomolecular Sciences
Telephone: +44 (0)1273 641912
+44 (0)1273 641186
Email: C.E.Marriott@brighton.ac.uk
Research Interests
- Developing more clinically reflective cell culture models for diabetes and cancer research.
- Investigating the effects of microgravity cell culture for the improvement of three dimensional islet-cell cluster function and viability
- Mimicking post-transplant in vivo conditions using a hypoxic environment to improve the outcome of pancreatic islet transplantation
- Investigating the effects of low oxygen (hypoxia) on tumour drug resistance to advance cancer therapy
- Biomaterial scaffolds for tissue replacement and drug delivery
Research Publications
Ferris, W.F., Marriott, C.E., Ali, T., Landy, C., Campbell, S.C. and Macfarlane, W.M. (2011) Tumor suppressor PDCD4 is a major transcript that is upregulated during in vivo pancreatic islet neogenesis and is expressed in both beta-cell and ductal cell lines Pancreas, 40 (1). pp. 61-66. ISSN 0885-3177
Ali, T., Landy, C, Marriott, C.E, Harrison, M and Macfarlane, W.M (2010) Imagining beta-cell lipotoxicity Diabetic Medicine, 27 (38). p. 5. ISSN 0742-3071
Persaud, S.J., Arden, C., Bergsten, P., Bone, A.J., Brown, J., Dunmore, S., Harrison, M., Hauge-Evans, A., Kelly, C., King, A., Maffucci, T., Marriott, C.E., McClenaghan, N., Morgan, N.G., Reers, C., Russell, M.A., Turner, M.D., Willoughby, E., Younis, M.Y.G., Zhi, Z.L. and Jones, P.M. (2010) Pseudoislets as primary islet replacements for research: report on a symposium at King's College London Islets, 2 (4). pp. 236-239. ISSN 1938-2014
MACFARLANE, WENDY, HARRISON, MOIRA and MARRIOTT, CLAIRE (2009) Mucin proteins form a key component of the extracellular matrix of three dimensional Min6 cell clusters Diabetes Supplement . p. 2416.
Ali, T., Landy, C., Marriott, C.E., Harrison, M. and Macfarlane, W.M. (2009) Rosiglitazone down-regulates p38 stress activated kinase and prevents pancreatic beta cells from lipotoxicity-induced dysfunction Diabetic Medicine, 26 (s1). p. 6. ISSN 0742-3071
Aldibbiat, A., Marriott, C.E., Scougall, K.T., Campbell, S.C., Huang, G.C., Macfarlane, W.M. and Shaw, J.A.M. (2008) Inability to process and store proinsulin in transdifferentiated pancreatic acinar cells lacking the regulated secretory pathway Journal of Endocrinology, 196 . pp. 33-43. ISSN 0022-0795
Landy, C., Ali, T., Crawford, R., Marriott, C.E., Woollhead, A.M., Harrison, M. and Macfarlane, W.M. (2008) Rosiglitazone modulates multiple signalling pathways in pancreatic beta cells and protects beta cells from the detrimental effects of free fatty acids Diabetes, 57 (Supplement 1A). p. 467. ISSN 0012-1797
Ali, T., Landy, C., Marriott, C.E, Crawford, R., Woollhead, A.M, Harrison, M. and Macfarlane, W.M (2008) Rosiglitazone prevents fatty acid induced increases in uncoupling protein 2 gene expression and protects pancreatic beta-cells from lipotoxicity Acta Diabetologica, 51 . p. 200. ISSN 0940-5429
Campbell, S.C., Aldibbiat, A., Marriott, C., Landy, C., Ali, T., Ferris, W.F., Butler, C.S., Shaw, J.A. and Macfarlane, W.M. (2008) Selenium stimulates pancreatic beta cell gene expression and enhances islet function FEBS Letters, 582 (15). pp. 2333-2337. ISSN 0014-5793
