Dr Gerry Gallacher
Principal Lecturer
contact:
Pharmacy and Biomolecular Sciences
Moulsecoomb
Brighton
BN2 4GJ
Telephone: +44 (0)1273 642033
Email: G.Gallacher@brighton.ac.uk
In 1990 Dr Gallacher jointly led the first group in the UK to report the production of catalytic antibodies. He is a leading authority in the field of catalytic antibodies. Dr Gallacher's background is in synthetic organic chemistry and medicinal chemistry.
Research Interests
- Synthetic Organic Chemistry - Design and synthesis of haptens, immunogens, prodrugs, and transition-state analogue inhibitors.
- Bio Organic Chemistry - Catalytic antibodies
- Medicinal Chemistry - Prodrugs and drug targetting (cancer).
- Immuno Chemistry - Generation of antibodies for the treatment of autoimmune
diseases and poisoning.
Recent Publications
Boucher, G, Said, B, Ostler, E, Resmini, M, Brocklehurst, K and Gallacher, G (2007) Evidence that the mechanism of antibody-catalysed hydrolysis of arylcarbamates can be determined by the structure of the immunogen used to elicit the catalytic antibody Biochemical Journal, 401 (3). pp. 721-726. ISSN 1470-8728
Sonkaria, S., Boucher, G., Florez-Alvarez, J., Said, B., Hussain, S., Ostler, E.L., Gul, S., Thomas, E.W., Resmini, M., Gallacher, G. and Brocklehurst, K. (2004) Evidence for ‘lock and key’ character in an anti-phosphonate hydrolytic antibody catalytic site augmented by non-reaction centre recognition: variation in substrate selectivity between an anti-phosphonate antibody, an anti-phosphate antibody and two hydrolytic enzymes Biochemical journal, 381 (1). pp. 125-130. ISSN 1470-8728
Gul, S., Sonkaria, S., Pinitglang, S., Florez-Alvarez, J., Hussain, S., Thomas, E.W., Ostler, E.L., Gallacher, G., Resmini, M. and Brocklehurst, K. (2003) Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the ‘flexibility’ hypothesis Biochemical journal, 376 (3). pp. 813-821. ISSN 1470-8728
Ostler, E.L., Resmini, M., Brocklehurst, K. and Gallacher, G. (2002) Polyclonal catalytic antibodies Journal of immunological methods, 269 (1-2). pp. 111-124. ISSN 0022-1759
Ostler, E.L., Dean, C.J., Barber, N., Valeri, M., James, S., Resmini, M., Boucher, G., Romanov, N., Brocklehurst, K. and Gallacher, G. (2002) A rat monoclonal antibody that catalyses the hydrolysis of a nitrophenyl-β-lactam Biochemical and biophysical research communications, 299 (2). pp. 273-276. ISSN 0006-291X
Florez-Alvarez, J., Brocklehurst, K., Gallacher, G. and Resmini, M. (2002) Synthesis of an aminoalcohol hapten for the generation of catalytic antibodies Tetrahedron Letters, 43 (1). pp. 171-174. ISSN 0040-4039
Ostler, E.L., Resmini, M., Boucher, G., Romanov, N., Brocklehurst, K. and Gallacher, G. (2002) Polyclonal antibody-catalysed hydrolysis of a beta-lactam Chemical communications . pp. 226-227. ISSN 1359-7345
