Prof Irene Green
Professor of Cellular Biochemistry
contact:
Pharmacy and Biomolecular Sciences
Moulsecoomb
Brighton
BN2 4GJ
Telephone: +44 (0)1273 644542
Email: I.C.Green@brighton.ac.uk
Research Interests
- Apoptosis signalling by nitric oxide and by cytokine-induced kinases.
- Differential gene and protein expression in rat or human islets of Langerhans.
- Mechanism of growth factor antagonism of fas and cytokine effects in vitro.
- DNA damage and repair measured following acute or chronic exposure to free radicals or cytokines.
- The role of nitric oxide synthase, heat shock proteins and free radical scavenging enzymes in beta cell damage and protection.
- Strategies to block cytokine effects in in vivo and in vitro systems, including in human islets of Langerhans and islets from animal models of diabetes.
Recent Publications
Beeharry, N., Chambers, J.A. and Green, I.C. (2004) Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition Apoptosis, 9 (5). pp. 599-607. ISSN 1573-675X
Rosales, A.L., Cunningham, J.M., Bone, A, Green, I.C. and Green, M.H.L. (2004) Repair of Cytokine-induced DNA damage in cultured rat islets of Langerhans Free radical research, 38 (7). pp. 665-674. ISSN 1029-2470
Beeharry, N., Chambers, J.A., Faragher, R.G.A., Garnett, K.E. and Green, I.C. (2004) Analysis of cytokine-induced NO-dependent apoptosis using RNA interference or inhibition by 1400W Nitric oxide: biology and chemistry, 10 (2). pp. 112-118. ISSN 1089-8611
Sigfrid, L.A., Cunningham, J.M., Beeharry, N., Borg, L.A.H., Hernandez, A.L.R., Carlsson, C., Bone, A and Green, I.C. (2004) Antioxidant enzyme activity and mRNA expression in the islets of Langerhans from the BB/S rat model of type 1 diabetes and an insulin-producing cell line Journal of molecular medicine, 82 . pp. 325-335. ISSN 1432-1440
Beeharry, N., Lowe, J.E., Hernandez, A.R., Chambers, J.A., Fucassi, F., Cragg, P.J., Green, M.H.L. and Green, I.C. (2003) Linoleic acid and antioxidants protect against DNA damage and apoptosis induced by palmitic acid Mutation research/fundamental and molecular mechanisms of mutagenesis, 530 (1-2). pp. 27-33. ISSN 0027-5107
Sigfrid, L.A., Cunningham, J.M., Beeharry, N., Lortz, S., Tiedge, M., Lenzen, S., Carlsson, C. and Green, I.C. (2003) Cytokines and nitric oxide inhibit the enzyme activity of catalase but not its protein or mRNA expression in insulin-producing cells Journal of molecular endocrinology, 31 (3). pp. 509-518. ISSN 1479-6813
Barry, R., Tadayyon, M. and Green, I.C. (2002) Reproducibility of targeted gene expression measurements in human islets of Langerhans Biochemical and biophysical research communications, 298 (3). pp. 350-356. ISSN 0006-291X
Conroy, S.J., Green, I.C., Dixon, G., Byrne, P.M., Nolan, J., Abdel-Wahab, Y.H.A., McClenaghan, N., Flatt, P.R. and Newsholme, P. (2002) Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed Type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion Journal of endocrinology, 173 (1). pp. 53-62. ISSN 1479-6805
