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Dr Irina Savina

Senior Lecturer

contact:
Pharmacy and Biomolecular Sciences
Moulsecoomb
Brighton
BN2 4GJ

Telephone: +44 (0)1273 642015

Email: I.N.Savina@brighton.ac.uk

 

Research Interests

Research fellow at School of Pharmacy and Biomolecular Science, University of Brighton.

Dr Irina Savina joined the University of Brighton in May 2007, from the University of Lund in Sweden. Her research interests cover a number of fields in the polymer chemistry and material science. She is a specialist in design and development of macroporous polymer gels, so called cryogels, which have attracted increasing interest as carriers of chromatography, protein synthesis, tissue engineering and others. Dr. Savina has extensive experience in macroporous gel preparation, controlling the pore structure in porous polymer material and in developing new methods of modification of the pore surface e.g. graft polymerization. She is currently focusing on preparation of new macroporous gels for biomedical and environmental applications, as well as studying factors controlling the pore structure in porous polymer gels and developing new methods of soft material assessment.

Relevant work experience

  • 1998-2003 Role of physicochemical properties of dispersed additives on the properties of poly(vinyl alcohol) (PVA) cryogel-type composites. Laboratory for Cryochemistry of Biopolymers, A.N.Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia.
  • October 2001 June 2002 Preparation of macroporous polymers for biotechnology. Department of Biotechnology, Centre for Chemistry and Chemical Engineering, Lund University, Sweden
  • November-December 2002 Preparation of composite gel materials for protein separation. Department of Chemical Enzymology, Faculty of Chemistry, Moscow State University, Russia
  • 2003 –2006 Methods of polymer surface modification and techniques of graft polymerization of vinyl monomers onto the gel surface within the large pores of polymer continuous gel. Preparation of macroporous materials for proteins, DNA and cell separation. Department of Biotechnology, Centre for Chemistry and Chemical Engineering, Lund University, Sweden
  • June-November 2006   Techniques of atom transfer radical polymerization for controlling surface chemistry in macroporous hydrogels Department of Organic Chemistry, Polymer Chemistry Research Group, Ghent University, Ghent, Belgium
  • January-May 2007 Preparation and characterization of macroporous polymer material for biomedical application. Protista BioTechnology AB, IDEON, Lund, Sweden,
  • May 2007-present Preparation and characterization of novel materials for wound healing and tissue regeneration and preparation of composite materials for environmental application. School of Pharmacy and Biomolecular Sciences, Visiting Senior Research Fellow, Brighton University, Brighton, UK.

Qualifications

  • 2003 Ph.D. degree in Chemistry, A.N.Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia
    Thesis: "Composite poly (vinyl alcohol) cryogels: preparation, influence of dispersed phase properties and applications”.
  • 1998 Teacher of Biology and Chemistry, Diploma with honour, Ryazan State Pedagogical University, Ryazan, Russia.
  • 1998 M.Sc. degree in Biology, specialization in Hyman Physiology, Ryazan State Pedagogical University, Ryazan, Russia.
    • The asymmetry of human brain, and its variation in the people of different professions”

Participation in Research Projects

  • 2001-2002 ”New generation of smart polymers and polymeric materials for biotechnology”, INTAS Grant 00-0057, Russia
  • 2003-2006 “Polymers designed for bioseparation”, Visby programm, Sweden
  • 2004-2006 “Nanoparticle separation. Virus and plasmid separation”, Swedish Bioseparation Centre, Sweden.
  • 2006 “Experimental Theoretical Design of Stimuli-Responsive Polymer Materials”, ESF program, Belgium
  • 2007-present “Biomaterials for wound healing and tissue regeneration”, FP6 project MTKI-CT-2006 – 042768 MATISS, Sweden and UK.
  • 2007-present, “Nanoclean – Nanoechnology for clean water”, CommercialiSE Proof of Concept (PoC), University of Brighton, UK
  • 2012-present,“BioSmart - Novel smart materials for biomedical application” , University of Brighton, UK

Award and Honours

Grant from the Swedish Institute (2001), Sweden
Grant from the Visby Program (2004), Sweden 
ESF Exchange Grant (2006), Belgium.   

Journals and Patents

Recent Publications

Number of items: 23.

Mikhalovsky, S.V., Savina, I.N., Dainiak, M., Ivanov, A. and Galaev, I.Y. (2012) Biomaterials/Cryogels In: Comprehensive biotechnology, 2nd Edition. Elsevier. (Submitted)

SAVINA, IRINA, ENGLISH, CHRISTOPHER, WHITBY, RAYMOND, ZHENG, YISHAN, Leistner, A., MIKHALOVSKY, SERGEY and CUNDY, ANDREW (2011) High efficiency removal of dissolved As(III) using iron nanoparticle-embedded macroporous polymer composites Journal of Hazardous Materials, 192 (3). ISSN 0304-3894

Junga, M., Dainiak, M.B., Sarnowska, A., Jablonska, A., Tripathi, A., Plieva , F.M., Savina, I.N., Strojek, L., Jungvid, H., Kumar, A., Lukomska, B., Domanska-Janik, K., Forraz, N. and McGuckin, C.P. (2011) The performance of laminin-containing cryogel scaffolds in neural tissue regeneration Biomaterials, 32 (13). pp. 3423-3434. ISSN 0142-9612

Savina, I.N., Gun'ko, V.M., Turov, V.V., Dainiak, M., Phillips, G.J, Galaev, I.Y. and Mikhalovsky, S.V. (2011) Porous structure and water state in cross-linked polymer and protein cryo-hydrogels Soft Matter, 2011 (7). pp. 4276-4283. ISSN 1744-683X

SHEVCHENKO, ROSTISLAV, Eeman, M., SAVINA, IRINA, ALLAN, IAIN, JAMES, STUART, Salmon, M., MIKHALOVSKY, SERGEY and JAMES, S.Elizabeth (2010) A step towards an artificial skin: a novel supermacroporous anisotropic cryogel for wound healing applications International Journal of Artificial Organs, 33 (7). ISSN 0391-3988

Gun'ko, V.M., Mikhalovska, L.I., Savina, I.N., Shevchenko, R.V., James, S.L., Tomlins, P.E. and Mikhalovsky, S.V. (2010) Characterisation and performance of hydrogel tissue scaffolds Soft Matter, 6 (21). pp. 5351-5358. ISSN 1744-683X

Mikhalovsky, S.V., Savina, I.N., Dainiak, M., Ivanov, A.E and Galaev, I.Y (2010) Cryogels In: Murray, M-Y. and Zhanfeng, C., eds. Comprehensive Biotechnology. Pergamon Press?.

Ivanov, A.E., Kumar, A., Nilsang, S., Aguilar , M.R., Mikhalovska, L.I., Savina, I.N., Nilsson, L., Scheblykin, I.G., Kuzimenkova, M.V. and Galaev, I.Y. (2010) Evaluation of boronate-containing polymer brushes and gels as substrates for carbohydrate-mediated adhesion and cultivation of animal cells Colloids and Surfaces B: Biointerfaces, 75 (2). pp. 510-519. ISSN 0927-7765

Dainiak, M., Allan, I., Savina, I.N., Cornelio, L., James, E., James, S.L., Mikhalovsky, S.V., Jungvid, H. and Galaev, I.Y. (2010) Gelatin-fibrinogen cryogel dermal matrices for wound repair I: preparation, optimisation and in vitro study Biomaterials, 31 (1). pp. 67-76. ISSN 0142-9612

Gun'ko, V.M., Mikhalovska, L.I., Savina, I.N., Shevchenko, R.V., James, S.L, Tomlins, P.E and Mikhalovsky, S.V. (2010) The hierarchy of pore sizes in hydrogel tissue engineering scaffolds and its effects on interactions with proteins and human skin fibroblasts Soft Materials . ISSN 1539-445X (In Press)

Savina, I.N., Dainiak, M., Jungvid, H., Mikhalovsky, S.V. and Galaev, I Yu. (2009) Biomimetic macroporous hydrogels: protein ligand distribution and cell response to the ligand architecture in the scaffold Journal of Biomaterials Science, 20 (12). pp. 1781-1795. ISSN 0920-5063

Savina, I.N., Tomlins, P.E, Mikhalovsky, S.V. and Galaev, I Yu. (2009) Characterization of macroporous gels In: Mattiasson, B., Kumar, A. and Galaev, I.Y, eds. Macroporous Polymers. Production Properties and Biotechnological/Biomedical Applications. CRC Press, London, New York, pp. 211-236.

Dainaik, M., Savina, I.N., Musolino, I., Kumar, A., Galaev, I Yu. and Mattiasson, B. (2008) Biomimetic macroporous hydrogel scaffolds in a high throughput screening format for cell-based assays Biotechnology Progress, 24 (8). pp. 1373-1383. ISSN 8756-7938

Savina, I.N., Cnudde, V., D'Hollander, S., Van Hoorebeke, L., Matiasson, B., Galaev, I.Y. and Du Prez, F. (2007) Cryogels from poly(2-hydroxyethyl methacrylate): macroporous, interconnected materials with potential as cell scaffolds Soft Matter, 3 (9). pp. 1176-1184. ISSN 1744-6848

Savina, I.N., Galaev, I.Y. and Mattiasson, B. (2006) Ion-exchange macroporous hydrophilic gel monolith with grafted polymer brushes Journal of Molecular Recognition, 19 (4). pp. 313-321. ISSN 0952-3499

Hanora, A, Savina, I.N., Plieva, F.M, Izumrudov, V.A, Mattiasson, B and Galaev, I.Y (2006) Direct capture of plasmid DNA from non-clarified bacterial lysate using polycation-grafted monoliths Journal of Biotechnology, 123 (3). pp. 343-355. ISSN 0168-1656

Savina, I.N., Mattiasson, B. and Galaev, I.Y. (2006) Graft polymerization of vinyl monomers inside macroporous polyacrylamide gel, cryogel, in aqueous and aqueous-organic media initiated by diperiodatocuprate(III) complexes Journal of Polymer Science Part A Polymer Chemistry, 44 (6). pp. 1952-1963. ISSN 1099-0518

Savina, I.N., Mattiasson, B. and Galaev, I.Y. (2005) Graft polymerization of acrylic acid onto macroporous polyacrylamide gel (cryogel) initiated by potassium diperiodatocuprate Polymer, 46 (23). pp. 9596-9603. ISSN 0032-3861

Savina, I.N., Galaev, I.Y and Mattiasson, B (2005) Anion-exchange supermacroporous monolithic matrices with grafted polymer brushes of N,N-dimethylaminoethyl-methacrylate Journal of Chromatography A, 1092 (2). pp. 199-205. ISSN 0021-9673

Plieva, F.M., Savina, I.N., Deraz, S., Andersson, J., Galaev, I.Y. and Mattiasson, B. (2004) Characterization of supermacroporous monolithic polyacrylamide based matrices designed for chromatography of bioparticles Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 807 (1). pp. 129-137. ISSN 1570-0232

Savina, I.N. and Lozinskii, V.I. (2004) Study of cryostructuring of polymer systems: 23. Composite poly(vinyl alcohol) cryogels filled with dispersed particles containing ionogenic groups Colloid Journal, 66 (3). pp. 343-349. ISSN 1068-3067

Arvidsson, P, Plieva, F.M, Savina, I.N., Lozinsky, V.I, Fexby, S, Bulow, L, Galaev, I.Y and Mattiasson, B (2002) Chromatography of microbial cells using continuous supermacroporous affinity and ion-exchange columns Journal of Chromatography A, 977 (1). pp. 27-38. ISSN 0021-9673

Lozinskii, V.I and Savina, I.N. (2002) Study of cryostructuring of polymer systems: 22. Composite poly(vinyl alcohol) cryogels filled with dispersed particles of various degrees of hydrophilicity/hydrophobicity Colloid Journal, 64 (3). pp. 336-343. ISSN 1068-3067

This list was generated on Tue Jun 11 16:17:15 2013 BST.