Prof John Smart
Academic Director of Pharmacy/Professor
Pharmacy and Biomolecular Sciences
Telephone: +44 (0)1273 642091
Prof. Smart graduated in 1979 with a BSc (Hons) degree in Pharmacy, Brighton
Polytechnic (now the University of Brighton), and completed his pharmacy preregistration
training year with Cyanamid of Great Britain Ltd, Gosport and Portsmouth Area
He then studied for PhD degree at the Welsh School of Pharmacy, U.W.I.S.T. before managing his own community pharmacy business for four years. In 1988 he was appointed Lecturer in Pharmaceutics, the School of Pharmacy and Biomedical Science, Portsmouth Polytechnic (now the University of Portsmouth), then became a Reader in Pharmaceutical Sciences (1997) and then Head of the School from August 1997 to September 2002.
During this period the School flourished, scoring highly in the research assessment exercise and subject reviews. He also led the School into the pioneering ‘New Generation’ interprofessional education project in collaboration with the University of Southampton. In February 2004 he returned to the University of Brighton as Head of the School of Pharmacy and Biomolecular Sciences and Professor of Pharmaceutical Sciences.
Prof. Smart’s research interests are in drug delivery using bioadhesive materials, specifically hydrophilic macromolecules and lectins; the multifunctional properties of these materials being of particular interest. Target sites investigated within the body include the eye, mouth, oesophagus, stomach and colon. He is also leading in the development of a UK-wide drug delivery network, as well as pursuing an interest in the quality and distribution of substandard medicines in developing countries.
Research related activities
He has acted as a referee for a range of journals, research councils and charities, been an invited speaker at seminars at several universities and pharmaceutical companies, involved with the organisation of national and international conferences, and given invited conference lectures, including recently at the American Association of Pharmaceutical Science Congress, the FIP World Congress and the British Pharmaceutical Conference,. He is currently a member of the editorial board of the Journal ‘Drug Delivery Systems and Commerce’, Euromed (Haslemere, UK) and the science committee of the council of the General Pharmaceutical Council (GPhC).
SMART, JOHN, Dunkley, S., Tsibouklis, J. and Young, S. (2013) An in vitro model for the evaluation of the adhesion of solid oral dosage forms to the oesophagus International Journal of Pharmaceutics, 447 (1-2). ISSN 0378-5173
SMART, JOHN (2012) Conference report: Nasal and Buccal Drug Delivery: Management Forum Conference Therapeutic Delivery, 3 (7). ISSN 2041-5990
Keegan, G.M., Smart, J.D., Ingram, M.J., Barnes, L.M., Burnett, G.R. and Rees, G.D. (2012) Chitosan microparticles for the controlled delivery of fluoride Journal of Dentistry, 40 (3). pp. 229-240. ISSN 0300-5712
Smart, J.D. (2011) Drug delivery systems and their potential for use in battlefield situations In: Mikhalovsky, S. and Khajibaev, A., eds. Biodefence. NATO Science for Peace and Security Series A: Chemistry and Biology (3). Springer, pp. 117-124.
SMART, JOHN and Keegan, Gemma (2010) Buccal drug delivery systems In: Wen, Hong and Park, Kinam, eds. Oral controlled release formulation design and drug delivery: theory to practice. John Wiley & Sons, New Jersey, pp. 169-184. ISBN 9780470253175
Gullick, D.R., Ingram, M.J., Pugh, W.J., Cox, P.A., Gard, P.R. and Smart, J.D. (2009) Metabolism of captopril carboxyl ester derivatives for percutaneous absorption Journal of Pharmacy & Pharmacology, 61 (2). pp. 159-165. ISSN 0022-3573
Churchley, D., Rees, G.D., Smart, J.D. and Tsibouklis, J. (2008) Fluoropolymers as low-surface-energy tooth coatings for oral care International Journal of Pharmaceutics, 352 (1-2). pp. 44-49. ISSN 0378-5173
Roldo, M, Barbu, E, Brown, J.F, Laight, D.W, Smart, J.D and Tsibouklis, J (2007) Azo compounds in colon-specific drug delivery Expert Opinion on Drug Delivery, 4 (5). pp. 547-560. ISSN 1742-5247
Keegan, G, Smart, J, Ingram, M, Barnes, L, Rees, G and Burnett, G (2007) An in vitro assesment of bioadhesive zinc/carbomer complexes for antimicrobial therapy within the oral cavity International Journal of Pharmaceutics, 340 (1-2). pp. 92-96. ISSN 0378-5173
Moss, G.P, Gullick, D.R, Cox, P.A, Alexander, C, Ingram, M.J, Smart, J.D and Pugh, W.J (2006) Design, synthesis and characterization of captopril prodrugs for enhanced percutaneous absorption Journal of Pharmacy and Pharmacology, 58 (2). pp. 167-177. ISSN 0022-3573
Smart, J.D. (2005) The basics and underlying mechanisms of mucoadhesion Advanced drug delivery reviews, 57 (11). pp. 1556-1568. ISSN 0169-409X
Kockisch, S., Rees, G.D., Tsibouklis, J. and Smart, J.D. (2005) Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity: preparation and controlled release characteristics European Journal of Pharmaceutics and Biopharmaceutics, 59 (1). pp. 207-216.
Kockisch, S., Rees, G.D., Young, S.A., Tsibouklis, J. and Smart, J.D. (2004) In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions International Journal of Pharmaceutics, 276 (1-2). pp. 51-58.
Smart, J.D. (2004) Lectin-mediated drug delivery in the oral cavity Advanced drug delivery reviews, 56 (4). pp. 481-489. ISSN 0169-409X
Smart, J.D. (2004) Recent developments in the use of bioadhesive systems for delivery of drugs to the oral cavity Critical reviews in therapeutic drug carrier systems, 21 (4). pp. 319-344. ISSN 0743-4863
Smart, J.D., Riley, R.G., Tsibouklis, J., Young, S.A., Hampson, F.C., Davis, J.A., Kelly, G., Dettmar, P.W. and Wilber, W.R. (2003) The retention of 14C-labelled poly(acrylic acids) on gastric and oesophageal mucosa: an in vitro study European journal of pharmaceutical sciences, 20 (1). pp. 83-90. ISSN 0928-0987
Kockisch, S., Rees, G.D., Young, S.A., Tsibouklis, J. and Smart, J.D. (2003) Polymeric microspheres for drug delivery to the oral cavity: An in vitro evaluation of mucoadhesive potential European Journal of Pharmaceutical Sciences, 92 (8). pp. 1614-1623.
Marsh, L.H., Alexander, C., Coke, M., Dettmar, P.W., Havler, M., Nevell, T.G., Smart, J.D., Timmins, B. and Tsibouklis, J. (2003) Adsorbed pluronics on the skin of human volunteers: effects on bacterial adhesion International Journal of Pharmaceutics, 251 (1-2). pp. 155-163.
Smart, J.D., Banchonglikitkul, C., Gibbs, R.V., Donovan, S.J. and Cook, D.J. (2003) Lectins in drug delivery to the oral cavity, in vitro toxicity studies STP Pharma Sciences, 13 . pp. 37-40. ISSN 1157-1489
Patel, M.M., Smart, J.D., Nevell, T.G., Ewen, R.J., Eaton, P.J. and Tsibouklis, J. (2003) Mucin/poly(acrylic acid) interactions: a spectroscopic investigation of mucoadhesion Biomacromolecules, 4 (5). pp. 1184-1190. ISSN 1526-4602
Marsh, L.H., Coke, M., Dettmar, P.W., Ewen, R.J., Havler, M., Nevell, T.G., Smart, J.D., Smith, J.R., Timmins, B., Tsibouklis, J. and Alexander, C. (2002) Adsorbed poly(ethyleneoxide)-poly(propyleneoxide) copolymers on synthetic surfaces: Spectroscopy and microscopy of polymer structures and effects on adhesion of skin-borne bacteria Journal of Biomedical Materials Research Part A, 61 (4). pp. 641-652. ISSN 1549-3296
Smart, J.D., Nantwi, P.K.K., Rogers, D.J. and Green, K.L. (2002) A quantitative evaluation of radiolabelled lectin retention on oral mucosa in vitro and in vivo European Journal of Pharmaceutics and Biopharmaceutics, 53 (3). pp. 289-292. ISSN 0939-6411
Eaton, P.J., Smith, J.R., Graham, P., Smart, J.D., Nevell, T.G. and Tsibouklis, J. (2002) Adhesion force mapping of polymer surfaces: factors influencing force of adhesion Langmuir, 18 (8). pp. 3387-3389. ISSN 0743-7463
Riley, R.G., Smart, J.D., Tsibouklis, J., Young, S.A., Hampson, F., Davis, A., Kelly, G., Dettmar, P.W. and Wilber, W.R. (2002) An in vitro model for investigating the gastric mucosal retention of 14C-labelled poly(acrylic acid) dispersions International journal of pharmaceutics, 236 (1-2). pp. 87-96. ISSN 0378-5173
Barbu, E., Pullin, R.A., Graham, P., Eaton, P.J., Ewen, R.J., Smart, J.D., Nevell, T.G. and Tsibouklis, J. (2002) Poly(di-1H,1H,2H,2H-perfluoroalkylitaconate) films: surface organisation phenomena, surface energy determinations and force of adhesion measurements Polymer, 43 (6). pp. 1727-1734. ISSN 0032-3861
Banchonglikitkul, C., Smart, J.D., Gibbs, R.V., Donovan, S.J. and Cook, D.J. (2002) An in-vitro evaluation of lectin cytotoxicity using cell lines derived from the ocular surface Journal of Drug Targeting, 10 (8). pp. 601-606. ISSN 1061-186X
Banchonglikitkul, C., Smart, J.D., Gibbs, R.V. and Cook, D.J. (2002) Lectins as targeting agents - the in vitro binding of lectins to lesions in the eye and mouth British Journal of Biomedical Science, 59 (2). pp. 115-118. ISSN 0967-4845
Riley, R.G., Smart, J.D., Tsibouklis, J., Davis, J.A., Kelly, G., Hampson, F., Dettmar, P.W. and Wilber, W.R. (2001) Synthesis of radiolabeled congeners of the carbomers: 14C-labeled poly(acrylic acid)s Journal of Biomedical Materials Research Part A, 58 (1). pp. 102-107. ISSN 1549-3296
Kockisch, S., Rees, G.D., Young, S.A., Tsibouklis, J. and Smart, J.D. (2001) A direct-staining method to evaluate the mucoadhesion of polymers from aqueous dispersion Journal of Controlled Release, 77 (1-2). pp. 1-6.
Riley, R.G., Green, K.L., Smart, J.D., Tsibouklis, J., Davis, J.A., Hampson, F., Dettmar, P.W. and Wilber, W.R. (2001) The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): an in vivo study Biomaterials, 22 (13). pp. 1861-1867. ISSN 0142-9612
Riley, R.G., Smart, J.D., Tsibouklis, J., Dettmar, P.W., Hampson, F., Davis, J.A., Kelly, G. and Wilber, W.R. (2001) An investigation of mucus/polymer rheological synergism using synthesised and characterised poly(acrylic acid)s International Journal of Pharmaceutics, 217 (1-2). pp. 87-100. ISSN 0378-5173