Dr Marcus Allen
Principal Lecturer
contact:
Pharmacy and Biomolecular Sciences
Moulsecoomb
Brighton
BN2 4GJ
Telephone: +44 (0)1273 642044
Email: M.C.Allen@brighton.ac.uk
Research Interests
- Ion Channel Pharmacology
Application of the electrophysiological techniques to the study membrane proteins.
- Pharmacology of oestrogens
Design, synthesis and testing of oestrogens that have novel pharmacological actions at the cell membranes.
- The pharmacological effects of ageing
- Expertise in patch clamp and black lipid bilayer electrophysiology for the investigation of membrane proteins
Society Memberships
- General Pharmaceutical Council (GPhC)
- The British Pharmacological Society
- The British Society for Research into ageing
- The European Tissue Culture Society
Research Grants and Funding Bodies
| BBSRC | Project | Construction of a well differentiated cell line from human corneal endothelium | £250,000 | 2003 |
| EPSRC | Project | Artificial Sodium Ion Channels | £102,223 | 1999 |
| Deutsche Forschungsgemeinschaft (DFG) | Project | Immortalisation Of Human Corneal Endothelial Cells | DM54,000 | 1999 |
| Wellcome Trust | Vacation Studentship | 5-HT3 Receptor Inhibition By Tamoxifen And Its Derivatives. | £1,080 | 1998 |
| Glaxo/Wellcome | Human Nasal H3 Receptors | £128,154 | 1995 | |
| Trevor Mann Baby Unit/ Rocking Horse Appeal | Project | Membrane Receptors & Serum Growth Factors As Markers Of Inter-Uterine Growth Retardation. | £8,500 | 1995 |
| John Harris Award For Clinical Pharmacy And Pharmacology | Studentship | Neuronal Cell Lines & H3 Receptors. | £920 | 1994 |
| Royal Pharmaceutical Society Summer Studentship | Vacation Studentship | Neuronal Cell Lines & H3 Receptors. | £1,170 | 1994 |
| Wellcome Trust | Vacation Studentship | Pulmonary H2 Receptors |
Research Publications
Sheerin, A, Smith, S.K., Jennert-Burston, K., Brook, A.J., Allen, M.C., Ibrahim, B., Jones , D.L., Wallis , C, Engelmann, K, Rhys-Williams, W, Faragher, R.G.A. and Kipling, D. (2012) Characterization of cellular senescence mechanisms in human corneal endothelial cells Aging Cell, 11 (2). pp. 234-240. ISSN 1474-9718
UNSPECIFIED (2010) Method for the stabilsation of purified P-glycoprotein .
Lawal, O., Iqbal, K.S.J., Mohamadi, A., Razavi, P., Dodd, H.T., Allen, M.C., Siddiqui, S., Fucassi, F. and Cragg, P.J. (2009) An artificial sodium ion channel from calix[4]arene in the 1,3-alternate conformation Supramolecular Chemistry , 21 (1-2). pp. 55-60. ISSN 1061-0278
Heikal, A., Box, K., Rothnie, A., Storm, J., Callaghan, R. and Allen, M.C. (2009) The stabilisation of purified, reconstituted P-glycoprotein by freeze drying with disaccharides Cryobiology, 58 (1). pp. 37-44. ISSN 0011-2240
Iqbal, K.S.J., Allen, M.C., Fucassi, F. and Cragg, P.J. (2007) Artificial transmembrane ion channels from commercial surfactants Chemical Communications, 38 . pp. 3951-3953. ISSN 1359-7345
GARD, PAUL, ALLEN, MARCUS and YEOMAN, MARK (2006) Changes in the properties of the modulatory cerebral giant cells contribute to aging in the feeding system of Lymnaea Neurobiology Of Aging, 27 (12). pp. 1892-1901. ISSN 0197-4580
Arundell, M, Patel, B.A, Straub, V, Allen, M.C., Janse, C, O'Hare, D, Parker, K, Gard, P.R and Yeoman, M.S (2006) Effects of age on feeding behavior and chemosensory processing in the pond snail, Lymnaea stagnalis Neurbiology og Aging, 27 (12). pp. 1880-1891. ISSN 0197-4580
De Wet, H, Allen, M.C., Holmes, C, Stobbart, M, Lippiat, J.D and Callaghan, R (2006) Modulation of the BK Channel by estrogens: examination at a single channel level Molecular Membrane Biology, 23 (5). pp. 420-429. ISSN 1464-5203
Patel, B.A., Arundell, M., Allen, M.C., Gard, P.R, Parker, K. and Yeoman, M.S. (2006) Changes in the properties of the modulatory cerebral giant cells contribute to aging in the feeding system of Lymnaea Neurobiology of Aging, 27 (12). pp. 1892-1901.
Burton, D.G.A., Allen, M.C., Bird, J.L.E. and Faragher, R.G.A. (2005) Bridging the gap: ageing, pharmacokinetics and pharmacodynamics Journal of pharmacy and pharmacology, 57 (6). pp. 671-680. ISSN 0022-3573
Otter, S.J., Robinson, C.J., James, D., Allen, M.C., Davies, Graham and Stew, G. (2003) An evaluation of an interdisciplinary joint clinical placement between podiatry and pharmacy students Pharmacy education, 3 (4). pp. 253-260. ISSN 1560-2214
Hardy, S.P., Ritchie, C., Allen, M.C., Ashley, R.H. and Granum, P.E. (2001) Clostridium perfringens type A enterotoxin forms mepacrine-sensitive pores in pure phospholipid bilayers in the absence of putative receptor proteins Biochimica et biophysica acta (BBA) - biomembranes, 1515 (1). pp. 38-43. ISSN 0005-2736
Sandeman, S.R., Faragher, R.G.A., Allen, M.C., Liu, C. and Lloyd, A.W. (2001) Does MMP-2 expression and secretion change with increasing serial passage of keratocytes in culture? Mechanisms of ageing and development, 122 (2). pp. 157-167. ISSN 1464-5203
Sahebgharani, M., Hardy, S.P., Lloyd, A.W., Hunter, A.C. and Allen, M.C. (2001) Volume-activated chloride currents in HeLa cells are blocked by Tamoxifen but not by a membrane impermeant quaternary analogue Cellular physiology and biochemistry, 11 (2). pp. 99-104. ISSN 1421-9778
