Prof Richard Faragher

RG Faragher
Professor

contact:
Pharmacy and Biomolecular Sciences
Cockcroft
Moulsecoomb
Brighton

Telephone: +44 (0)1273 642124

Email: R.G.A.Faragher@brighton.ac.uk

Research Interests

We "do" senescence. Why do we do this? Because it has been suggested for over 30 years that the phenomenon of cell senescence may be linked in some way to human ageing. Senescence is the progressive replicative failure of a population of cells to divide in culture. Once senescent, cells exhibit a wide range of changes in phenotype and gene expression which give them the potential to alter the behaviour of any tissue in which they are found. In its modern form the cell hypothesis of ageing suggests that the progressive accumulation of such senescent cells (as a result of ongoing tissue turnover) may contribute to the ageing process.

Recent Publications

Burton, D, Sheerin, A, Ostler, E.L, Smith, K, Giles, P.J, Lowe, J, Rhys-Williams, W, Kipling, D.G and Faragher, R.G.A (2007) Cyclin D1 over-expression permits the reproducible detection of senescent human vascular smooth muscle cells. Annals of the New York Academy of Sciences, 1119. pp. 20-31. ISSN 1-57331-686-5

Thill, M, Schlanger, K, Altenahr, S, Ergun, S, Faragher, R.G.A, Bednarz, J, Vohwinkel, G, Rogiers, X, Hossfeld, D.K, Richard, G and Gehling, U.M (2007) A novel population of repair cells identified in the stroma of the human cornea. Stem Cells and Development, 16 (5). pp. 733-746. ISSN 1547-3287

Fucassi, F, Lowe, J.E, Pavey, K.D, Shah, S, Faragher, R.G.A, Green, M.H.L., Paul, F, O'Hare, D and Cragg, P.J (2007) alpha-Lipoic acid and glutathione protect against the prooxidant activity of SOD/catalase mimetic manganese salen derivatives. Journal of Inorganic Biochemistry, 101 (2). pp. 225-232. ISSN 0162-0134

Burton, D.G.A., Allen, M.C., Bird, J.L.E. and Faragher, R.G.A. (2005) Bridging the gap: ageing, pharmacokinetics and pharmacodynamics. Journal of pharmacy and pharmacology, 57 (6). pp. 671-680. ISSN 0022-3573

Davis, T., Skinner, J.W., Faragher, R.G.A., Jones, C.J. and Kipling, D. (2005) Replicative senescence in sheep fibroblasts is a p53 dependent process. Experimental gerontology, 40 (1-2). pp. 17-26. ISSN 0531-5565

Mehta, J.S., Futter, C.E., Sandeman, S.R., Faragher, R.G.A., Hing, K.A., Tanner, K.E. and Allan, B.D.S. (2005) Hydroxyapatite promotes superior keratocyte adhesion and proliferation in comparison with current keratoprosthesis skirt materials. British journal of ophthalmology, 89 (10). pp. 1356-1362. ISSN 0007-1161

Corso, C., Parry, E.M., Faragher, R.G.A., Seager, A., Green, M.H.L. and Parry, J.M. (2005) Molecular cytogenetic insights into the ageing syndrome Hutchinson-Gilford Progeria (HGPS). Cytogenetic and genome research, 111 (1). pp. 27-33. ISSN 1424-8581

Kipling, D., Davis, T., Ostler, E.L. and Faragher, R.G.A. (2004) What can progeroid syndromes tell us about human aging? Science, 305 (5689). pp. 1426-1431. ISSN 1095-9203

Lowe, J., Sheerin, A., Jennert-Burston, K., Burton, D., Ostler, E.L., Bird, J., Green, M.H.L. and Faragher, R.G.A. (2004) Camptothecin sensitivity in Werner syndrome fibroblasts as assessed by the COMET technique. Annals of the New York Academy of Sciences, 1019. pp. 256-259. ISSN 1749-6632

Davis, T., Faragher, R.G.A., Jones, C.J. and Kipling, D. (2004) Investigation of the signaling pathways involved in the proliferative life span barriers in Werner syndrome fibroblasts. Annals of the New York academy of sciences, 1019. pp. 274-277. ISSN 0077-8923

Wallis, C.V., Sheerin, A.N., Green, M.H.L., Jones, C.J., Kipling, D. and Faragher, R.G.A. (2004) Fibroblast clones from patients with Hutchinson–Gilford progeria can senesce despite the presence of telomerase. Experimental gerontology, 39 (4). pp. 461-467. ISSN 0531-5565

Beeharry, N., Chambers, J.A., Faragher, R.G.A., Garnett, K.E. and Green, I.C. (2004) Analysis of cytokine-induced NO-dependent apoptosis using RNA interference or inhibition by 1400W. Nitric oxide: biology and chemistry, 10 (2). pp. 112-118. ISSN 1089-8611

Bird, J., Ostler, E.L. and Faragher, R.G.A. (2003) Can we say that senescent cells cause ageing? Experimental gerontology, 38 (11-12). pp. 1319-1326. ISSN 0531-5565

Lim, K.S., Khaw, P.T, Faragher, R.G.A, Gard, P.R, Olliff, C.J, Hanlon, G.W, Wong, L, Reed, S, Denyer, S.P, Allan, B, Willlis, S and Miur, A (2003) Corneal endothelial cell damage from glaucoma drainage device materials. Cornea, 22 (4). pp. 352-354. ISSN 0277-3740

Davis, T., Singhrao, S.K., Wyllie, F.S., Haughton, M.F., Smith, P.J., Wiltshire, M., Wynford-Thomas, D., Jones, C.J., Faragher, R.G.A. and Kipling, D. (2003) Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms. Journal of cell science, 116. pp. 1349-1357. ISSN 1477-9137

Ostler, E.L., Wallis, C.V., Sheerin, A.N. and Faragher, R.G.A. (2002) A model for the phenotypic presentation of Werner's syndrome. Experimental gerontology, 37 (2-3). pp. 285-292. ISSN 0531-5565

Lim, K.S., Allan, B., Khaw, P.T., Willis, S., Lloyd, A.W., Muir, A., Gard, P.R., Faragher, R.G.A., Olliff, C.J., Hanlon, G.W., Wong, L., Reed, S. and Denyer, S.P. (2001) Experimental flow studies in glaucoma drainage device development. British journal of ophthalmology, 85 (10). pp. 1231-1236. ISSN 0007-1161

Yeoman, M.S. and Faragher, R.G.A. (2001) Ageing and the nervous system: insights from studies on invertebrates. Biogerontology, 2 (2). pp. 85-97. ISSN 1573-6768

Lloyd, A.W., Faragher, R.G.A. and Denyer, S.P. (2001) Ocular biomaterials and implants. Biomaterials, 22 (8). pp. 769-985. ISSN 0142-9612

Sandeman, S.R., Faragher, R.G.A., Allen, M.C., Liu, C. and Lloyd, A.W. (2001) Does MMP-2 expression and secretion change with increasing serial passage of keratocytes in culture? Mechanisms of ageing and development, 122 (2). pp. 157-167. ISSN 1464-5203

This list was generated on Tue Feb 9 17:32:30 GMT 2010.