Prof Richard Faragher
Asst Head of Sch./Prof of Biogerentology
contact:
Pharmacy and Biomolecular Sciences
Moulsecoomb
Brighton
BN2 4GJ
Telephone: +44 (0)1273 642124
Email: R.G.A.Faragher@brighton.ac.uk
Research Interests
We "do" senescence. Why do we do this? Because it has been suggested for over 30 years that the phenomenon of cell senescence may be linked in some way to human ageing. Senescence is the progressive replicative failure of a population of cells to divide in culture. Once senescent, cells exhibit a wide range of changes in phenotype and gene expression which give them the potential to alter the behaviour of any tissue in which they are found. In its modern form the cell hypothesis of ageing suggests that the progressive accumulation of such senescent cells (as a result of ongoing tissue turnover) may contribute to the ageing process.
Recent Publications
FARAGHER, RICHARD and YEOMAN, MARK (2012) Insights into CNS ageing from animal models of senescence Nature Reviews Neuroscience, 13 (6). ISSN 1471-003X
Sheerin, A, Smith, S.K., Jennert-Burston, K., Brook, A.J., Allen, M.C., Ibrahim, B., Jones , D.L., Wallis , C, Engelmann, K, Rhys-Williams, W, Faragher, R.G.A. and Kipling, D. (2012) Characterization of cellular senescence mechanisms in human corneal endothelial cells Aging Cell, 11 (2). pp. 234-240. ISSN 1474-9718
FARAGHER, RICHARD and OSTLER, ELIZABETH (2012) Editorial: a systematic end to "muddling through"? [Edited Collections]
Bird, J.L.E, JENNERT-BURSTON, KATRIN, Bacheler, M.A., Mason, P.A., Lowe, J.E., Heo, S.J., Campisi, J., FARAGHER, RICHARD and Cox, L.S. (2012) Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease Biogerontology, 13 (1). ISSN 1389-5729
Faragher, R.G.A., Burton, D, Majecha, P., Fong, N.S., Davis, T, Sheerin, A and Ostler, E.L. (2011) Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts AGE, 33 (4). pp. 555-564. ISSN 0161-9152
Ostler, E.L., Iqbal, A., Faragher, R.G.A., Naughton, D., Piper, M. and Partridge, L. (2011) Chemical analysis of aging: Testing predictions from green theory In: 40th American Aging Association Annual Meeting 2011, 2011.
Iqbal, Aamira, Piper, M., Faragher, R.G.A., Naughton, D.P., Partridge, L. and Ostler, E.L. (2009) Chemical changes in aging Drosophila melanogaster Age, 31 (4). pp. 343-351. ISSN 0161-9152
SHEERIN, ANGELA, OSTLER, ELIZABETH and FARAGHER, RICHARD (2009) Microarray analysis of senescent vascular smooth muscle cells: a link to atherosclerosis and vascular calcification Experimental Gerontology, 44 (10). pp. 659-665. ISSN 0531-5565
Faragher, R.G.A., Sheerin, A. and Ostler, E.L. (2009) Can we intervene in human ageing? Expert Reviews in Molecular Medicine, 11 (e27). ISSN 1462-3994
FARAGHER, RICHARD (2009) The in vitro kinetics of senescence of Fischer 344 rat embryo fibroblasts Biogerontology, 10 (3). pp. 285-289. ISSN 1389-5729
Kipling, D., Jones , D.L., Smith, S.K., Giles, P.J., Jennet-Burston, K., Ibrahim, B., Sheerin, A.N., Evans, A.J., Rhys-Willams, W. and Faragher, R.G.A. (2009) A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescence Experimental Eye Research, 88 (2). pp. 277-285. ISSN 0014-4835
FARAGHER, RICHARD (2008) Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity Bioessays, 30 (6). pp. 567-578. ISSN 0265-9247
Burton, D, Sheerin, A, Ostler, E.L, Smith, K, Giles, P.J, Lowe, J, Rhys-Williams, W, Kipling, D.G and Faragher, R.G.A (2007) Cyclin D1 over-expression permits the reproducible detection of senescent human vascular smooth muscle cells Annals of the New York Academy of Sciences, 1119 . pp. 20-31. ISSN 1-57331-686-5
Thill, M, Schlanger, K, Altenahr, S, Ergun, S, Faragher, R.G.A, Bednarz, J, Vohwinkel, G, Rogiers, X, Hossfeld, D.K, Richard, G and Gehling, U.M (2007) A novel population of repair cells identified in the stroma of the human cornea Stem Cells and Development, 16 (5). pp. 733-746. ISSN 1547-3287
Fucassi, F, Lowe, J.E, Pavey, K.D, Shah, S, Faragher, R.G.A, Green, M.H.L., Paul, F, O'Hare, D and Cragg, P.J (2007) alpha-Lipoic acid and glutathione protect against the prooxidant activity of SOD/catalase mimetic manganese salen derivatives Journal of Inorganic Biochemistry, 101 (2). pp. 225-232. ISSN 0162-0134
Burton, D.G.A., Allen, M.C., Bird, J.L.E. and Faragher, R.G.A. (2005) Bridging the gap: ageing, pharmacokinetics and pharmacodynamics Journal of pharmacy and pharmacology, 57 (6). pp. 671-680. ISSN 0022-3573
SANDEMAN, SUSAN and FARAGHER, RICHARD (2005) Hydroxyapatite promotes superior keratocyte adhesion and proliferation in comparison with current keratoprosthesis skirt materials British Journal of Ophthalmology, 89 (10). pp. 1356-1362. ISSN 0007-1161
Davis, T., Skinner, J.W., Faragher, R.G.A., Jones, C.J. and Kipling, D. (2005) Replicative senescence in sheep fibroblasts is a p53 dependent process Experimental gerontology, 40 (1-2). pp. 17-26. ISSN 0531-5565
Corso, C., Parry, E.M., Faragher, R.G.A., Seager, A., Green, M.H.L. and Parry, J.M. (2005) Molecular cytogenetic insights into the ageing syndrome Hutchinson-Gilford Progeria (HGPS) Cytogenetic and genome research, 111 (1). pp. 27-33. ISSN 1424-8581
Kipling, D., Davis, T., Ostler, E.L. and Faragher, R.G.A. (2004) What can progeroid syndromes tell us about human aging? Science, 305 (5689). pp. 1426-1431. ISSN 1095-9203
Lowe, J., Sheerin, A., Jennert-Burston, K., Burton, D., Ostler, E.L., Bird, J., Green, M.H.L. and Faragher, R.G.A. (2004) Camptothecin sensitivity in Werner syndrome fibroblasts as assessed by the COMET technique Annals of the New York Academy of Sciences, 1019 . pp. 256-259. ISSN 1749-6632
Davis, T., Faragher, R.G.A., Jones, C.J. and Kipling, D. (2004) Investigation of the signaling pathways involved in the proliferative life span barriers in Werner syndrome fibroblasts Annals of the New York academy of sciences, 1019 . pp. 274-277. ISSN 0077-8923
Wallis, C.V., Sheerin, A.N., Green, M.H.L., Jones, C.J., Kipling, D. and Faragher, R.G.A. (2004) Fibroblast clones from patients with Hutchinson–Gilford progeria can senesce despite the presence of telomerase Experimental gerontology, 39 (4). pp. 461-467. ISSN 0531-5565
Beeharry, N., Chambers, J.A., Faragher, R.G.A., Garnett, K.E. and Green, I.C. (2004) Analysis of cytokine-induced NO-dependent apoptosis using RNA interference or inhibition by 1400W Nitric oxide: biology and chemistry, 10 (2). pp. 112-118. ISSN 1089-8611
Bird, J., Ostler, E.L. and Faragher, R.G.A. (2003) Can we say that senescent cells cause ageing? Experimental gerontology, 38 (11-12). pp. 1319-1326. ISSN 0531-5565
Lim, K.S., Khaw, P.T, Faragher, R.G.A, Gard, P.R, Olliff, C.J, Hanlon, G.W, Wong, L, Reed, S, Denyer, S.P, Allan, B, Willlis, S and Miur, A (2003) Corneal endothelial cell damage from glaucoma drainage device materials Cornea, 22 (4). pp. 352-354. ISSN 0277-3740
Davis, T., Singhrao, S.K., Wyllie, F.S., Haughton, M.F., Smith, P.J., Wiltshire, M., Wynford-Thomas, D., Jones, C.J., Faragher, R.G.A. and Kipling, D. (2003) Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms Journal of cell science, 116 . pp. 1349-1357. ISSN 1477-9137
OSTLER, ELIZABETH, Wallis, C.V, SHEERIN, ANGELA and FARAGHER, RICHARD (2002) A model for the phenotypic presentation of Werner's syndrome Experimental Gerontology, 37 (2-3). ISSN 0531-5565
Lim, K.S., Allan, B., Khaw, P.T., Willis, S., Lloyd, A.W., Muir, A., Gard, P.R., Faragher, R.G.A., Olliff, C.J., Hanlon, G.W., Wong, L., Reed, S. and Denyer, S.P. (2001) Experimental flow studies in glaucoma drainage device development British journal of ophthalmology, 85 (10). pp. 1231-1236. ISSN 0007-1161
Yeoman, M.S. and Faragher, R.G.A. (2001) Ageing and the nervous system: insights from studies on invertebrates Biogerontology, 2 (2). pp. 85-97. ISSN 1573-6768
Lloyd, A.W., Faragher, R.G.A. and Denyer, S.P. (2001) Ocular biomaterials and implants Biomaterials, 22 (8). pp. 769-985. ISSN 0142-9612
Sandeman, S.R., Faragher, R.G.A., Allen, M.C., Liu, C. and Lloyd, A.W. (2001) Does MMP-2 expression and secretion change with increasing serial passage of keratocytes in culture? Mechanisms of ageing and development, 122 (2). pp. 157-167. ISSN 1464-5203


