Dr Wendy Macfarlane
Reader
contact:
Pharmacy and Biomolecular Sciences
Moulsecoomb
Brighton
BN2 4GJ
Telephone: +44 (0)1273 642101
Email: W.M.Macfarlane@brighton.ac.uk
Research Interests
- Novel therapy for diabetes through generation of insulin-producing cell clusters.
- Regulation of islet beta-cell function by rosiglitazone and Exenatide
- Novel cell based hypoxic models to investigate liver and pancreatic cancer
- Role of programmed cell death gene Pdcd4 in islet neogenesis and pancreatic cancer.
- Identification of novel drug targets in type 2 diabetes
- Identification and isolation of adult stem cells from human pancreas
- Biomimetic 3-dimensional culture of stem cells on novel polymer scaffolds
Diabetes Research Group
Recent Publications
Forster, Richard, Yiqing, Tang, Bowyer, Cressida, LLOYD, ANDREW, MACFARLANE, WENDY, PHILLIPS, GARY and Lewis, Andrew (2012) Development of a combination drug-eluting bead: towards enhanced efficacy for locoregional tumour therapies Anti-Cancer Drugs, 23 (4). ISSN 0959-4973
Ferris, W.F., Marriott, C.E., Ali, T., Landy, C., Campbell, S.C. and Macfarlane, W.M. (2011) Tumor suppressor PDCD4 is a major transcript that is upregulated during in vivo pancreatic islet neogenesis and is expressed in both beta-cell and ductal cell lines Pancreas, 40 (1). pp. 61-66. ISSN 0885-3177
MACFARLANE, WENDY, PHILLIPS, GARY and LLOYD, ANDREW (2010) Comparison of DC Bead-irinotecan and DC Bead-topotecan drug eluting beads for use in locoregional drug delivery to treat pancreatic cancer Journal of Materials Science: Materials in Medicine, 21 (9). pp. 2683-2690. ISSN 0957-4530
LLOYD, ANDREW and MACFARLANE, WENDY (2010) Characterisation of physico-mechanical properties and degradation potential of calcium alginate beads for use in embolisation Journal of Materials Science: Materials in Medicine, 21 (7). pp. 2243-2251. ISSN 0957-4530
Ali, T., Landy, C, Marriott, C.E, Harrison, M and Macfarlane, W.M (2010) Imagining beta-cell lipotoxicity Diabetic Medicine, 27 (38). p. 5. ISSN 0742-3071
MACFARLANE, WENDY, HARRISON, MOIRA and MARRIOTT, CLAIRE (2009) Mucin proteins form a key component of the extracellular matrix of three dimensional Min6 cell clusters Diabetes Supplement . p. 2416.
Ali, T., Landy, C., Marriott, C.E., Harrison, M. and Macfarlane, W.M. (2009) Rosiglitazone down-regulates p38 stress activated kinase and prevents pancreatic beta cells from lipotoxicity-induced dysfunction Diabetic Medicine, 26 (s1). p. 6. ISSN 0742-3071
Macfarlane, W.M (2009) Pancreas biology, pathology and tissue engineering In: Santin, M, ed. Strategies in regenerative medicine: integrating biology with materials design. Springer, New York, USA.
Aldibbiat, A., Marriott, C.E., Scougall, K.T., Campbell, S.C., Huang, G.C., Macfarlane, W.M. and Shaw, J.A.M. (2008) Inability to process and store proinsulin in transdifferentiated pancreatic acinar cells lacking the regulated secretory pathway Journal of Endocrinology, 196 . pp. 33-43. ISSN 0022-0795
Landy, C., Ali, T., Crawford, R., Marriott, C.E., Woollhead, A.M., Harrison, M. and Macfarlane, W.M. (2008) Rosiglitazone modulates multiple signalling pathways in pancreatic beta cells and protects beta cells from the detrimental effects of free fatty acids Diabetes, 57 (Supplement 1A). p. 467. ISSN 0012-1797
Ali, T., Landy, C., Marriott, C.E, Crawford, R., Woollhead, A.M, Harrison, M. and Macfarlane, W.M (2008) Rosiglitazone prevents fatty acid induced increases in uncoupling protein 2 gene expression and protects pancreatic beta-cells from lipotoxicity Acta Diabetologica, 51 . p. 200. ISSN 0940-5429
Campbell, S.C., Aldibbiat, A., Marriott, C., Landy, C., Ali, T., Ferris, W.F., Butler, C.S., Shaw, J.A. and Macfarlane, W.M. (2008) Selenium stimulates pancreatic beta cell gene expression and enhances islet function FEBS Letters, 582 (15). pp. 2333-2337. ISSN 0014-5793
Campbell, S.C, Richardson, H, Ferris, W.F, Butler, C.S and Macfarlane, W.M (2007) Nitric oxide stimulates insulin gene transcription in pancreatic beta-cells. Biochemical and Biophysical Research Communications, 353 (4). pp. 1011-1016. ISSN 1090-2104
Richardson, H, Campbell, S.C, Smith, S.A and Macfarlane, W.M (2006) Effects of rosiglitazone and metformin on pancreatic beta cell gene expression Diabetologia, 49 (4). pp. 685-696. ISSN 1432-0428
Macfarlane, W.M (2006) Approaches to beta-cell regeneration and neogenesis In: Shapiro, E and Shaw, J, eds. Islet transplantation and beta-cell replacement therapy. Marcel Dekker Inc.
Macfarlane, W.M., Richardson, H, Campbell, S.C. and Smith, S.A. (2006) Effects of Rosiglitazone and Metformin on pancreatic beta-cell gene expression Diabetologia, 49 (4). pp. 685-696. ISSN 0012-186X
Ferris, W.F, van der Merwe, L, Campbell, S.C and Macfarlane, W.M (2005) Glucocorticoid administration and brief occlusion of the main pancreatic duct are likely to increase islet mass by a similar mechanism Pancreas, 31 (2). pp. 132-137. ISSN 0885-3177
Shepherd, L.M.A, Campbell, S.C and Macfarlane, W.M (2004) Transcriptional regulation of the IAPP gene in pancreatic beta-cells Biochimica Et Biophysica Acta-Gene Structure and Expression, 1681 (1). pp. 28-37. ISSN 0167-4781
Campbell, S.C and Macfarlane, W.M (2002) Regulation of the pdx1 gene promoter in pancreatic beta-cells Biochemical and Biophysical Research Communications, 299 (2). pp. 277-284. ISSN 1090-2104
Weng, J, Macfarlane, W.M, Lehto, M, Gu, H.F, Shepherd, L.M, Ivarsson, S.A, Wibell, L, Smith, T and Groop, L.C (2001) Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations Diabetologia, 44 (2). pp. 249-258. ISSN 1432-0428
