Adsorbents and adsorbent based technologies are one of the expanding areas of research within the Biomedical Materials Research Group.
The adsorbent-based research projects are funded by the Research Council, Department of Trade and Industry, small commercial companies and the European Union. This research group has interdisciplinary expertise in the production and evaluation of novel adsorbents for the adsorption of small molecules, immune mediators and other endogenous toxins. The areas of interest include the use of adsorbent technologies for treatment of patients with sepsis, kidney failure, undergoing cardio-pulmonary by-pass and as a preventative or therapeutic method of treatment for chemical, biological or radionucleotide exposure. The main focus is the development of biomaterials which aim to improve the quality of life of the population and reduce the costs of providing medical care.
Scanning electron micrograph of spherical carbon based adsorbent
Scanning electron micrograph of carbon based adsorbent demonstrating mesoporous structure
Scanning electron micrograph of blood in contact with material surface
Carbon Adsorbents - Recent Publications
- Melillo M, Gun'ko VM, Tennison SR, Mikhalovska LI, Phillips GJ, Davies JG, Lloyd AW, Kozynchenko OP, Malik DJ, Streat M, Mikhalovsky SV (2004) Structural characteristics of activated carbons and ibuprofen adsorption affected by bovine serum albumin Langmuir 20 (7): 2837-2851
- Melillo M, Phillips GJ, Davies JG, Lloyd AW, Tennison SR, Kozynchenko OP, Mikhalovsky SV (2004) The effect of protein binding on ibuprofen adsorption to activated carbons, Carbon 42 (3):565-571
- Sandeman S.R., Howell. C.A., Phillips G.J., Lloyd A.W., Davies, J.G., Mikhalovsky S.V., Tennison, S. R., Rawlinson, A. P., Kozynchenko, O. P., Owen H.L.H., Gaylor J.D.S., Rouse J.J., Courtney J.M. (2005) Assessing the In Vitro Biocompatibility of a Novel Carbon Device for the Treatment of Sepsis, Biomaterials (26); 7124 - 7131
- Murphy MC, Phillips GJ, Davies JG, Lloyd AW, Mikhalovsky SV. Removal of pro-inflammatory cytokines from biological media using adsorptive filtration. Filtration, 1 (1): 23-30 (2005)
- Ajzan A., Modine T, Punjabi P., Ganeshalingam K., Phillips G., Gourlay T. (2006) Quantification of Fat Mobilization in Patients Undergoing Coronary Artery Revascularization Using Off –pump and On-pump Techniques, Journal of Extracorporeal Technology; 38: 116-121
- Howell. C.A., Sandeman, S.R., Phillips, G.J., Lloyd, A.W., Davies, J.G., Mikhalovsky, S.V., Tennison, S.R., Rawlinson, A.P., Kozynchenko, O.P., Owen, H.L.H., Gaylor, J.D.S., Rouse, J.J, Courtney, J.M. (2006) Assessing the cytokine adsorption potential of a Novel Carbon Device for the Treatment of Sepsis, Biomaterials (27); 5286-5291
- Yushin G., Hoffman E.N., Barsoum M.W., Gogotsi Y., Howell C.A., Sandeman S.R., Phillips G.J., Lloyd A.W., Mikhalovsky S.V. (2006) Mesoporous carbide-derived carbon with porosity tuned for efficient cytokine adsorption, Biomaterials, 27; 5755-5762
- L.V. Karabanova, A.W. Lloyd, S.V. Mikhalovsky, M. Helias, G.J. Phillips, S. Rose, L. Mikhalovska, G. Boiteux, L.M. Sergeeva, E.D. Lutsyk, A. Svyatyna (2006) “Polyurethane/Poly(hydroxyethyl methacrylate) semi-Interpenetrating polymer networks for biomedical applications” Journal of Materials Science: Materials in Medicine. 17:1283-1296 ISSN 0957-4530
- Han, H.M., Mikhalovsky, S.V., Phillips G.J., Lloyd, A.W. (2007) Calcium phosphate sonoelectrodeposition on carbon fabrics and its effect on osteoblast cell viability in vitro, New Carbon Materials, 22 (2); 121-125
