Output
Publications
Cervellini I, Annenkov A, Brenton T, Chernajovsky Y, Ghezzi P, Mengozzi M. Erythropoietin (EPO) increases myelin gene expression in CG4 oligodendrocyte cells through the classical EPO receptor. Mol Med. 2013 Jun 27. doi: 10.2119/molmed.2013.00013.
Cervellini I, Sacre S, Ghezzi P, Mengozzi M. Erythropoietin does not affect TNF and IL-6 production directly. J Biol Regul Homeost Agents. 2013 Jan-Mar;27(1):189-96.
Cervellini I, Ghezzi P, Mengozzi M. Therapeutic efficacy of erythropoietin in experimental autoimmune encephalomyelitis in mice, a model of multiple sclerosis. Methods Mol Biol. 2013;982:163-73.
Ghezzi P, Conklin D. Tissue-protective cytokines: structure and evolution. Methods Mol Biol. 2013;982:43-58.
Ghezzi P. Protein glutathionylation in health and disease. Biochim Biophys Acta. 2013 May;1830(5):3165-72.
Pulman KG, Smith M, Mengozzi M, Ghezzi P, Dilley A. The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model. Neuroscience. 2013 Mar 13;233:174-83.
Mengozzi M, Cervellini I, Villa P, Erbayraktar Z, Gökmen N, Yilmaz O, Erbayraktar S, Manohasandra M, Van Hummelen P, Vandenabeele P, Chernajovsky Y, Annenkov A, Ghezzi P. Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9617-22.
Hagemeyer N, Boretius S, Ott C, Von Streitberg A, Welpinghus H, Sperling S, Frahm J, Simons M, Ghezzi P, Ehrenreich H. Erythropoietin attenuates neurological and histological consequences of toxic demyelination in mice. Mol Med. 2012 Feb 29. doi: 10.2119/molmed.2011.00457. [Epub ahead of print] PubMed PMID: 22396019.
Bianchi R, Cervellini I, Porretta-Serapiglia C, Oggioni N, Burkey B, Ghezzi P, Cavaletti G, Lauria G. Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy. J Pharmacol Exp Ther. 2012 Jan;340(1):64-72. Epub 2011 Oct 7.
Coppo L, Ghezzi P. Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism. Biochem Soc Trans. 2011 Oct;39(5):1268-72. Review.
Ghezzi P. Role of glutathione in immunity and inflammation in the lung. Int J Gen Med. 2011 Jan 25;4:105-13.
Dinarello C, Arend W, Sims J, Smith D, Blumberg H, O'Neill L, Goldbach-Mansky R, Pizarro T, Hoffman H, Bufler P, Nold M, Ghezzi P, Mantovani A, Garlanda C, Boraschi D, Rubartelli A, Netea M, van der Meer J, Joosten L, Mandrup-Poulsen T, Donath M, Lewis E, Pfeilschifter J, Martin M, Kracht M, Muehl H, Novick D, Lukic M, Conti B, Solinger A, Kelk P, van de Veerdonk F, Gabel C. IL-1 family nomenclature. Nat Immunol. 2010 Nov;11(11):973. Erratum in: Nat Immunol. 2011 Mar;12(3):271. Peyman, Kelk [corrected to Kelk, Peyman].
Ghezzi P, Bernaudin M, Bianchi R, Blomgren K, Brines M, Campana W, Cavaletti G, Cerami A, Chopp M, Coleman T, Digicaylioglu M, Ehrenreich H, Erbayraktar S, Erbayraktar Z, Gassmann M, Genc S, Gokmen N, Grasso G, Juul S, Lipton SA, Hand CC, Latini R, Lauria G, Leist M, Newton SS, Petit E, Probert L, Sfacteria A, Siren AL, Talan M, Thiemermann C, Westenbrink D, Yaqoob M, Zhu C. Erythropoietin: not just about erythropoiesis. Lancet. 2010 Jun 19;375(9732):2142. Erratum in: Lancet. 2010 Aug 7;376(9739):418. Bernaudinb, Myriam [corrected to Bernaudin, Myrian]; Bianchic, Roberto [corrected to Bianchi, Roberto].
Felix Clanchy and Sandra Sacre. Modulation of TLR function has therapeutic potential in auto-immune disease. Expert Opinion On Biological Therapy (2010) 10(12):1703-16.
Priora R, Coppo L, Salzano S, Di Simplicio P, Ghezzi P. Measurement of mixed disulfides including glutathionylated proteins. Methods Enzymol. 2010; 473:149-59. Review.
Bigini P, Steffensen KR, Ferrario A, Diomede L, Ferrara G, Barbera S, Salzano S, Fumagalli E, Ghezzi P, Mennini T, Gustafsson JA. Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease. J Neuropathol Exp Neurol. 2010 Jun;69(6):593-605.
Fioredda F, Calvillo M, Lanciotti M, Lanza T, Giunti L, Castagnola E, Lorenzi I, Tonelli R, Ghezzi P, Dufour C. Pegfilgrastim in children with severe congenital neutropenia. Pediatr Blood Cancer. 2010 Mar;54(3):465-7.
Lauria G, Campanella A, Filippini G, Martini A, Penza P, Maggi L, Antozzi C, Ciano C, Beretta P, Caldiroli D, Ghelma F, Ferrara G, Ghezzi P, Mantegazza R. Erythropoietin in amyotrophic lateral sclerosis: a pilot, randomized, double-blind, placebo-controlled study of safety and tolerability. Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):410-5.
Midwood K., Piccinini, A and Sacre S.M. Targeting toll-like receptors in autoimmunity. Curr Drug Targets. (2009) 10:1139-1155.
Porta C, Rimoldi M, Raes G, Brys L, Ghezzi P, Di Liberto D, Dieli F, Ghisletti S, Natoli G, De Baetselier P, Mantovani A, Sica A. Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14978-83.
Brines M, Patel NS, Villa P, Brines C, Mennini T, De Paola M, Erbayraktar Z, Erbayraktar S, Sepodes B, Thiemermann C, Ghezzi P, Yamin M, Hand CC, Xie QW, Coleman T, Cerami A. Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10925-30.
Mengozzi M, Cervellini I, Bigini P, Martone S, Biondi A, Pedotti R, Gallo B, Barbera S, Mennini T, Boraso M, Marinovich M, Petit E, Bernaudin M, Bianchi R, Viviani B, Ghezzi P. Endogenous erythropoietin as part of the cytokine network in the pathogenesis of experimental autoimmune encephalomyelitis. Mol Med. 2008 Nov-Dec;14(11-12):682-8. Epub 2008 Jul 30.
Mennini T, De Paola M, Bigini P, Mastrotto C, Fumagalli E, Barbera S, Mengozzi M, Viviani B, Corsini E, Marinovich M, Torup L, Van Beek J, Leist M, Brines M, Cerami A, Ghezzi P. Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo. Mol Med. 2006 Jul-Aug;12(7-8):153-60.
Hepburn AL, Mason JC, Wang S, Shepherd CJ, Florey O, Haskard DO, Davies KA. Both Fcgamma and complement receptors mediate transfer of immune complexes from erythrocytes to human macrophages under physiological flow conditions in vitro.Clin Exp Immunol. 2006;146:133-45.
Laragione T, Gianazza E, Tonelli R, Bigini P, Mennini T, Casoni F, Massignan T, Bonetto V, Ghezzi P. Regulation of redox-sensitive exofacial protein thiols in CHO cells. Biol Chem. 2006 Oct-Nov;387(10-11):1371-6.
Villa P, van Beek J, Larsen AK, Gerwien J, Christensen S, Cerami A, Brines M, Leist M, Ghezzi P, Torup L. Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives. J Cereb Blood Flow Metab. 2007 Mar;27(3):552-63.
Garau A, Bertini R, Mosca M, Bizzarri C, Anacardio R, Triulzi S, Allegretti M, Ghezzi P, Villa P. Development of a systemically-active dual CXCR1/CXCR2 allosteric inhibitor and its efficacy in a model of transient cerebral ischemia in the rat. Eur Cytokine Netw. 2006 Mar;17(1):35-41.
Ghezzi P, Casagrande S, Massignan T, Basso M, Bellacchio E, Mollica L, Biasini E, Tonelli R, Eberini I, Gianazza E, Dai WW, Fratelli M, Salmona M, Sherry B, Bonetto V. Redox regulation of cyclophilin A by glutathionylation. Proteomics. 2006 Feb;6(3):817-25.
Savino C, Pedotti R, Baggi F, Ubiali F, Gallo B, Nava S, Bigini P, Barbera S, Fumagalli E, Mennini T, Vezzani A, Rizzi M, Coleman T, Cerami A, Brines M, Ghezzi P, Bianchi R. Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis. J Neuroimmunol. 2006 Mar;172(1-2):27-37.
Fratelli M, Goodwin LO, Ørom UA, Lombardi S, Tonelli R, Mengozzi M, Ghezzi P. Gene expression profiling reveals a signalling role of glutathione in redox regulation. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13998-4003.
P Norsworthy, E Theodoridis, M Botto, P Athanassiou, C Gordon, D Isenberg, MJ Walport and KA Davies. Over-representation of the Fcg RIIA R131/R131 genotype in Caucasoid patients with autoantibodies to C1q. Arthritis and Rheumatism (1999) 42, 1828-1832
Hepburn AL, Mason JC, Davies KA. Expression of Fc-gamma and complement receptors on peripheral blood monocytes in systemic lupus erythematosus and rheumatoid arthritis. Rheumatology (Oxford). (2004);43:547-54.
KA Davies, MG Robson, AM Peters, P Norsworthy, JT Nash, and MJ Walport. Defective Fc-dependent processing of immune complexes in patients with systemic lupus erythematosus. Arthritis and Rheumatism, (2003) 46, 1028-1038.
MG Robson MG, HT Cook, M Botto, PR Taylor, N Busso, R Salvi, CD Pusey CD, MJ Walport MJ, and KA Davies. Accelerated nephrotoxic nephritis is exacerbated in C1q-deficient mice. Journal of Immunology, (2001) 166, 6820-8.