Surface-induced thrombosis and infection are two main complications which cause failure of medical devices. Device-related thrombosis is associated with activation of blood clotting and platelets adhesion and activation. Infection of the implanted devices occurred as a result of bacteria adhesion to the biomaterial surface. A genuinely biocompatible polymer for blood contacting devices should have both antithrombotic and antibacterial functionalities as both types of complication lead to an increase in morbidity, extended hospital stay and mortality.
In order to prevent device-induced thrombosis and infection, novel dual function polymer materials – thromboresistant and antimicrobial – will be produced. A novel and original approach that involves construction of multifunctional coatings, which combine formulation of the nitric oxide (NO) generating surface with the ability to prevent bacterial adhesion, capacity to inhibit platelet adhesion and the surface-bound argatroban drug will be applied to inhibit any surface-produced thrombin. The polymer matrices chosen for the design of dual function materials are the most commonly used synthetic polymers; polyurethane (PU) and polyvinylchloride (PVC) and the biopolymer collagen.
This project will be hosted by the multi-disciplinary Biomaterials and Medical Devices Research group at School of Pharmacy and Biomolecular Sciences. The project builds on the research from the previous FP6 IRSES Compositum and FP7 IRSES Nanobiomat projects, completed by the group, which also included Dr Liana Azizova as a visiting Research Fellow and co-author for the current DUALFUN project.
This project is due to commence in September 2017 and will end in September 2019.
This project has received funding of EUR 195,455 from the European Union’s Horizon 2020 research and innovation programme through the Marie Skłodowska-Curie Actions initiative. Marie Skłodowska-Curie Actions (MSCA) provide grants for all stages of researchers' careers and encourage transnational, intersectoral and interdisciplinary mobility. The MSCA enable research-focused organisations to host talented foreign researchers and to create strategic partnerships with leading institutions worldwide. Dr Liana Azizova is supported as a Marie Skłodowska-Curie Fellow to complete this project; her MSCA application achieved one of the highest evaluation scores in the 2016 competitive selection from over 8000 proposals.
This project has received funding from the Marie Skłodowska-Curie Actions (MSCA) Individual Fellows (IF) under the European Union’s Horizon 2020 research and innovation programme under grant agreement number 749207.
The overarching aim of this project is to develop novel dual function polymer materials to prevent device-induced thrombosis and infection.
This aim will be achieved by:
Catecholamines, polydopamine and poly(norepinephrine) will be used as the surface modification reagents, as they form very stable thin films strongly attached to the polymer surface. Owing to the chemical bonding of the ligand to the polymer surface it is expected that these materials will have long storage life and exploitation period and therefore retain their ability to generate NO from the inexhaustible endogenous NO donors.
This project is ongoing; output, findings and impact will be updated in due course.
Dr Jim Cunningham, Principal Investigator
Dr Liana Azizova, Marie Skłodowska-Curie Actions (MSCA) Individual Fellow
Professor Sergey Mikhalovsky
Dr Lyuba Mikhalovska
Dr Iain Allan
This project is ongoing; output will be updated in due course.