HTLV-1, which has homologues in simian populations (STLV), is a retrovirus which can cause a fatal adult T-cell leukaemia (ATL) in five -10 per cent of infected patients for which there is currently no effective treatment.
The Ecosystems and environmental management research group is investigating a number of mechanisms whereby HTLV-1 proteins can precipitate the development of ATL, with a particular emphasis on the ability of the viral proteins Tax and HBZ to induce proliferative responses and down-regulate programmed cell death.
The project runs from January 2016 to September 2016 (initially). This work is also the subject of a University of Brighton 'Rising Stars' application.
Currently, there is no effective treatment for ATL and these studies may provide therapeutic pointers to deal with this and other related retroviruses which, like HIV, have the potential to transfer into human populations.
This project is currently ongoing and findings will be added on completion.
Dr Simon Jeffs
To be added on completion of the project
Professor Graham Taylor, Imperial College London