Projects per year
Personal profile
Research interests
My research centers on the function of the tumour microenvironment in tumour progression and metastasis. My particular interest lies in the role of tumour associated macrophages (TAMs). I investigate TAM plasticity, heterogeneity and recruitment, and their function in tumour growth and spread. I have also been investigating the versatile effects of chemokine signalling in the tumour microenvironment.
Supervisory Interests
I supervise projects that investigate tumour associated macrophage subsets and how their gene expression changes in reponse to drug treatments. My projects also study how the pro-tumour macrophages can be selectively targeted for therapeutic purposes.
Education/Academic qualification
Fulbright Scholarship, UT MD Anderson Cancer Center
1998 → 1999
Fellow of the Higher Education Academy, Higher Education Academy, UK
Master, Teratogenic effects of vitamin A and its derivatives, Semmelweis University
PhD, The effects of perinatal steroid treatment on retinoid receptor binding capacity , Semmelweis University
External positions
Review Editor in Inflammation, Frontiers in Immunology
27 Aug 2018 → …
Keywords
- RB Pathology
- cancer
- tumour associated macrophages
- inflammation
- metastasis
- Q Science (General)
- chemokines
- cytokines
- epithelial-mesenchymal transition
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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Evolving polarisation of infiltrating and alveolar macrophages in the lung during metastatic progression of melanoma suggests CCR1 as a therapeutic target
Tapmeier, T., Howell, J., Zhao, L., Papiez, B. W., Schnabel, J. A., Muschel, R. & Gal, A., 14 Oct 2022, In: Oncogene. 41, 46, p. 5032-5045 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Identification of Prognostic Gene Biomarkers in Non-Small Cell Lung Cancer Progression by Integrated Bioinformatics Analysis
Giannos, P., Kechagias, K. & Gal, A., 18 Nov 2021, In: Biology. 10, 11, 1200.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Targeting tumour associated macrophages in anti-cancer therapies
Gal, A., 5 Jan 2018, p. 0-0. 1 p.Research output: Contribution to conference › Other
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Plasticity of macrophages in the tumour microenvironment
Gal, A., 12 Dec 2017, p. 0-0. 1 p.Research output: Contribution to conference › Other
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Blocking the recruitment of tumor promoting macrophages leads to resident macrophages modulating the immune response in pulmonary metastasis of melanoma
Gal, A., Tapmeier, T. & Muschel, R., 4 Apr 2016, p. 0-0. 1 p.Research output: Contribution to conference › Abstract › peer-review