Dr Sreejith Raveendran

Dr Sreejith Raveendran is a Marie Skłodowska-Curie Fellow working on the GLIOMA project. He graduated with his PhD in Bionanoscience with an emphasis on cancer drug delivery and nanomedicine from Toyo University, Japan in 2013. After acquiring his doctoral degree from Bio Nano Electronics Research centre, he is pursuing his nanoresearch in cancer nanotechnology and targeted nanotherapy through the postdoctoral research position.

Dr Raveendran focuses on the novel combinatorial approaches in immunochemo therapies of cancer and infectious diseases via bio-nanotechnological platforms. He synthesises and characterises novel nanoparticle formulations with multiple functional moieties, chemotherapeutic agents and imaging modalities that specifically bind to the target proteins in cancer cells. He studies the cellular and molecular mechanisms behind the nanoparticle toxicity, drug activity and immunological stimulations after specific targeting through new multimodal therapeutics. His expertise is not limited to nanotechnology but microbiology, immunology, cancer biology, tissue engineering, material science, molecular biology, bioengineering and microscopy. He worked as research associate in infection pharmacology at AstraZeneca India Pvt. Ltd., and Junior Research Associate in Abl Biotechnologies Ltd., India, during his early career.

Sreejith-Raveendran

How I like to teach

My teaching philosophy is simple but coherent. A person and their character can be molded both personally and professionally through the process of teaching and learning. My way of teaching involves strategic approaches that comprise curriculums with rigorous theoretical and practical sessions. I believe in interactive teaching, which is more appropriate to ensure excellence in every aspect of learning that includes the subject knowledge, interpersonal skills and time management. Theory sessions encompassing lectures, seminars, and assignments after thorough literature review will help students and budding researchers to develop their subject knowledge while performing research experiments.

My teaching interests are predominantly focused in the areas of microbiology, cancer biology, immunology, bionanoscience, biomaterials, bioengineering and nanotechnology. Presently, I emphasise my research-oriented studies in nanotherapy of cancers and infectious diseases via multimodal therapeutic approaches and biomaterial based nanoformulations.

My research interests

My research interests are in cancer immunotherapy and cancer-cell biology; developing novel nanoformulations for cancer-drug delivery and chemo-immunotherapy as well as stimulating immune cells and immune response by targeting cancer cells using novel nanoparticles functionalised with immunomodulating agents. My present research targets the development of a nanovaccine for treating cancers by proper immunological stimulation through site-directed delivery of chemotherapeutic agents, immunogens and siRNA. I focus in studying the cancer cell and molecular biology of mammalian cells including cellular response to nanomaterials like autophagy pathway, apoptosis, mitochondrial and lysosomal interactions, immune cells and antibody studies, and immunofluorescence.

Research activity

Current research projects

  • GLIOMA (H2020- MSCA-IF- 749403) (2017- 2019)

Previous research projects

  • Development of therapeutic gold nanocages for parallel killing of breast cancer cells through type I and type II cell death. (Programme for the Strategic Research Foundation at Private Universities, S1101017- MEXT, Japan 2012- 2016).
  • MEXT 2010 fellowship for doctoral studies. Prospects of extremophiles & sulfated polysaccharides in bionanotechnology and biomedicine (2010- 2013).

Research centres and groups

Biomaterials and medical devices

Social media

Linked In

ResearchGate

Google Scholar

Contact me

Dr Sreejith Raveendran

Dr Raveendran's address, email and telephone number will be updated in October 2017.

Biography

In 2013, I completed and received my PhD in Bionanoscience with an emphasis on cancer drug delivery and nanomedicine from Toyo University in Japan. After acquiring my doctoral degree from Bio Nano Electronics Research centre, I have been pursuing my nanoresearch in cancer nanotechnology and targeted nanotherapy through the postdoctoral research position.

Presently, I am focusing on novel combinatorial approaches in immunochemo therapies of cancer and infectious diseases via bio-nanotechnological platforms. I synthesise & characterise novel nanoparticle formulations with multiple functional moieties, chemotherapeutic agents and imaging modalities that specifically binds to the target proteins in cancer cells. Also, I am studying the cellular and molecular mechanisms behind the nanoparticle toxicity, drug activity and immunological stimulations after specific targeting through new multimodal therapeutics. My expertise is not limited to nanotechnology but microbiology, immunology, cancer biology, tissue engineering, material science, molecular biology, bioengineering and microscopy. This shows the pure multidisciplinary nature of my research encompassing medicine, life science and engineering.

I worked as a research associate in infection pharmacology at AstraZeneca India Pvt. Ltd., and junior research associate in Abl Biotechnologies Ltd., India, during my early career. The progress as an early career researcher has been recognised on several occasions including awards such as the Marie Sklodowska Curie Action Individual Fellowship 2016, NANOSMAT Best Poster Award 2014, MEXT Fellowship 2010, University First Rank and Gold Medal for Master of Science Examination 2007.

Research output

Ultra-fast microwave aided synthesis of gold nanocages and structural maneuver studies. Sreejith Raveendran, Anindito Sen, Toru Maekawa, Sakthi Kumar. Nano Research, 2016, 10 (3), 1078-1091.

Dual mode of cancer cell destruction for pancreatic cancer therapy using Hsp90 inhibitor loaded polymeric nano magnetic formulation. Ankit  K. Rochani, Sivakumar Balasubramanian, Aswathy Ravindran Girija, Sreejith  Raveendran, Ankita  Borah, Yutaka Nagaoka, Yoshikata Nakajima,Toru Maekawa, D. Sakthi Kumar. International Journal of Pharmaceutics, 2016, 511, 648- 658.

Targeting self-renewal pathways in cancer stem cells: Clinical implications for cancer therapy. Ankita Borah, Sreejith Raveendran, Ankit Rochani, Toru Maekawa, D. Sakthi Kumar. Oncogenesis, 2015, 4, e177; doi:10.1038/oncsis.2015.35 .

Extremophilic polysaccharide nanoparticles for cancer nanotherapy and evaluation of antioxidant properties. Sreejith Raveendran, Vivekanandan Palaninathan, Yutaka Nagaoka, Takahiro Fukuda, Seiki Iwai, Toshiaki Higashi, Toru Mizuki, Yasushi Sakamoto, P. V. Mohanan, Toru Maekawa, D. Sakthi Kumar. International Journal of Biological Macromolecules, 2015, 76, 310- 319.

N2 Plasma assisted one- step alignment and patterning of graphene oxide on SiO2 /Si substrate via Langmuir Blodgett technique. Neha Chauhan, Vivekanandan Palaninathan, Sreejith Raveedran, Aby C. Poulose, Yoshikata Nakajima, Takashi Hasumura, Takashi Uchida, Tatsuro Hanajiri, Toru Maekawa, D. Sakthi Kumar. Advanced Materials Interfaces, 2015, 2, 1400515.

Keratin degradation by bacteria and fungi isolated from poultry farm and plumage. Sivakumar Nallusamy and Sreejith Raveendran. British Poultry Science, 2015, 56 (2), 210- 217.

Acetosulfation of bacterial cellulose: An unexplored promising incipient candidate for highly transparent thin film. Vivekanandan Palaninathan, Neha Chauhan, Aby Cheruvathoor Poulose, Sreejith Raveendran, Toru Mizuki, Takashi Hasumura, Takahiro Fukuda, Hisao Morimoto,Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar. Material Express, 2014, 4(5), 415-421.

Extremophilic polysaccharide for biosynthesis and passivation of gold nanoparticles and photothermal ablation of cancer cells. Sreejith Raveendran, Neha Chauhan, Vivekanandan Palaninathan, Yutaka Nagaoka, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar. Particle & Particle System Characterization, 2015, 32, 54-64

Bacterial exopolysaccharide based magnetic nanoparticles: A versatile nanotool for cancer cell imaging, targeted drug delivery and synergistic effect of drug and hyperthermia mediated cancer therapy. Sivakumar Balasubramanian, Aswathy Ravindran Girija, Sreejith Raveendran, Yutaka Nagaoka, Seki Iwai, Masashi Suzuki, Takahiro Fukuda, Takshi Hasumura, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar. Journal of Biomedical Nanotechnology, 2014, 10, 885-899.

Evaluation of toxicity of maura reduced graphene oxide using in vitro systems. Reshma. S. Cherian#, Sreejith Raveendran#, Syama. S, Sruthi. S, Gayathri. V, Toru Maekawa, D. Sakthi Kumar, Mohanan PV. (# Authors equally contributed). Journal of Nanomedicine & Nanotechnology , 2014, 5:3.

Green approach for augmenting biocompatibility of quantum dots by extremophilic polysaccharide conjugation and nontoxic bioimaging. Sreejith Raveendran, Aswathy Ravindran Girija, Sivakumar Balasubramanian, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar. ACS Sustainable Chemistry & Engineering, 2014, 2 (7), 1551- 1558.

In vitro evaluation of antioxidant defence mechanism and hemocompatibility of mauran. Sreejith Raveendran, Vivekanandan Palaninathan, Neha Chauhan, Yasushi Sakamoto, Yasuhiko Yoshida, Toru Maekawa, P. V. Mohanan, D. Sakthi Kumar. Carbohydrate Polymers, 2013, 98; 108- 115.

Aptamer conjugated paclitaxel and magnetic fluid loaded fluorescently tagged PLGA nanoparticles for targeted cancer therapy.. Athulya Aravind, Remya Nair, Sreejith Raveendran, Srivani Veeranarayanan, Yutaka Nagaoka, Takahiro Fukuda, Takahashi Hasumura, Hisao Morimoto, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar. Journal of Magnetism and Magnetic Materials 2013, 344; 116- 123.

Pharmaceutically versatile sulfated polysaccharide based bionano platforms. Sreejith Raveendran, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar.  Nanomedicine: Nanotechnology, Biology and Medicine, 2013, 9; 605-626.

Ecofriendly route for synthesis of highly conductive graphene using extremophiles for green electronics and bioscience. Sreejith Raveendran, Neha Chauhan, Yoshikata Nakajima, Higashi Toshiaki, Shunji    Kurosu, Yuji Tanizawa, Ryugo Tero, Yasuhiko Yoshida, Tatsuro Hanajiri, Toru Maekawa, Pulickel. M. Ajayan, Adarsh Sandhu, D. Sakthi Kumar. Particle & Particle System Characterization, 2013, 30; 573- 578.

Biocompatible nanofibers based on extremophilic bacterial polysaccharides from Halomonas maura. Sreejith Raveendran, Brahatheeswaran Dhandayuthapani, Yutaka Nagaoka, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar. Carbohydrate Polymers, 2013, 92; 1225-1233.

Bacterial polysaccharide based nanoparticles for sustained drug delivery, cancer chemotherapy and bioimaging. Sreejith Raveendran, Aby. C. Poulose, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar. Carbohydrate Polymers, 2013, 91; 22- 32.

Multifunctional biocompatible fluorescent carboxymethyl cellulose nanoparticles. Aswathy Ravindran Girija, Sivakumar Balasubramanian, Brahatheeswaran Dhandayuthapani, Sreejith Raveendran, Tomufomi Ukai, Takahiro Fukuda, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar. Journal of Biomaterials and Nanobiotechnology. 2012, 3; 254- 261.

PEG Coated Biocompatible Cadmium Chalcogenide Quantum Dots for Targeted Imaging of Cancer Cells. Aby. C. Poulose, Srivani Veeranarayanan, Sheikh Mohammed, Sreejith Raveendran, Yutaka Nagaoka, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar. Journal of Fluorescence, 2012, 22 (3); 931- 944.

Awards

Horizon 2020-MaSCA-IF-2016- Marie-Sklodowska-Curie Individual Fellowship, 2016.

Nanosmat Poster prize- International Conference on Surfaces,

Coatings and Nanostructured Materials, Trinity College, Dublin, Ireland, 2014.

Student Grant Award- International conference on Nanoscience + Technology (ICNT), Paris, France.

Monbukagakusho-MEXT fellowship, MEXT Japan, 2010.

University First Rank Master of Science in Microbiology, Bharathidasan University, India.

Gold Medal for achieving university first rank, J. J. college of Arts & Science, India.
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