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Strand-banner-image
Centre for Stress and Age-Related Disease
  • What we do
  • Who we work with
  • Study or work with us
  • Who we are
  • What we do
    • What we do
    • Cell biology
    • Chemical biology
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  • Cell Biology

Cell Biology

Cell biology of chronic disease

Chronic diseases have considerable societal impact. Patients with long-term conditions now account for about 50 per cent of all GP appointments, 64 per cent of all outpatient appointments and over 70 per cent of all inpatient bed days. Scientists within the Cell Biology theme have research expertise which works at the interface between chemistry, biochemistry and pharmacology.

Our research encompasses a variety of conditions with the overarching goal of understanding cellular mechanisms and developing novel therapeutic approaches. Specific emphasis is placed on the roles played by stress, inflammation and the natural ageing process in a range of disease conditions, including:

  • Arthritis
  • Cardiovascular Disease
  • Cancer
  • Constipation
  • Diabetes
  • Foetal Alcohol Syndrome
  • HIV
  • Hypertension
  • Multiple Sclerosis.
MRM-LHP-breast-cancer

Download the Psychological stress in patients with breast cancer (pdf) article from the Making research matter publication.

Cell biology research and enterprise projects

STRAND-CNS-ageing

Effects of age on the central nervous system

STRAND-pancreatic-islets-cellular-models-of-diabetes

Type 1 Diabetes - cause and cure

STRAND-clinically-reflective-T1D

Clinically reflective cellular model systems for Type 1 diabetes

Improving current clinical protocols in cell replacement therapy.

STRAND-neuropeptides-growth

The effects of pre-natal alcohol on adolescent learning and memory

STRAND-Gi-tract-ageing

Effects of age on signalling and function in the lower bowel

STRAND-combatting-CNS-myelination

Combating disorders of CNS myelination

STRAND-inflammation-and-immunity-thumbnail

C-Stress project

Marcus-allen-BK-channel-project

BK channels as pharmacological targets for therapeutic intervention

STRAND-inflamation-and-immunity

Inflammation and Immunity

STRAND-electrochemical-sensors

Electrochemical sensor devices to aid understand of ageing and disease mechanisms

Liver-damage

Hepatic disease

STRAND-Proteomic

Proteomic and Genomic analysis of cellular stress responses

Team-verrico-logo

Exploring the role of the ADRB2 in triple negative breast cancer

BCRT-logo

Stress hormones in BRCA mutation carriers

Paul Jackson, Simon Booth, Dr Brian Jones

Antibiotic efficacy in treating wound infection

STRAND-Proteomic

Interaction between sensory and supporting cells in the organ of Corti: basis for sensitivity and frequency selectivity of mammalian cochlea

Antibiotics-project

Regulation of stress responses and antibiotic production by Streptomyces bacteria

CPSmith_Vitamin_D_project_image

Exploiting genomics to understand the role of vitamin D in human health and metabolism

Research Team

  • Dr Marcus Allen
  • Dr Lucas Bowler
  • Professor Richard Farragher
  • Dr Melanie Flint
  • Professor Paul Gard
  • Dr Fergus Guppy
  • Dr Jon Mabley
  • Dr Wendy M Macfarlane
  • Dr Bhavik Patel
  • Dr Angela Sheerin
  • Dr Graham Sheridan
  • Professor Colin Smith
  • Dr Nadia Terrazzini
  • Professor David Timson
  • Dr Mark Yeoman
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