• Skip to content
  • Skip to footer
  • Accessibility options
University of Brighton
  • About us
  • Business and
    employers
  • Alumni and
    supporters
  • For
    students
  • For
    staff
  • Accessibility
    options
Open menu
Home
Home
  • Close
  • Study here
    • Get to know us
    • Why choose Brighton?
    • Explore our prospectus
    • Chat to our students
    • Ask us a question
    • Meet us
    • Open days and visits
    • Virtual tours
    • Applicant days
    • Meet us in your country
    • Campuses
    • Our campuses
    • Our city
    • Accommodation options
    • Our halls
    • Helping you find a home
    • What you can study
    • Find a course
    • Full A-Z course list
    • Explore our subjects
    • Our academic departments
    • How to apply
    • Undergraduate application process
    • Postgraduate application process
    • International student application process
    • Apprenticeships
    • Transfer from another university
    • International students
    • Clearing
    • Funding your time at uni
    • Fees and financial support
    • What's included in your fees
    • Brighton Boost – extra financial help
    • Advice and guidance
    • Advice for students
    • Guide for offer holders
    • Advice for parents and carers
    • Advice for schools and colleges
    • Supporting you
    • Your academic experience
    • Your wellbeing
    • Your career and employability
  • Research
    • Research and knowledge exchange
    • Research and knowledge exchange organisation
    • The Global Challenges
    • Centres of Research Excellence (COREs)
    • Research Excellence Groups (REGs)
    • Our research database
    • Information for business
    • Community University Partnership Programme (CUPP)
    • Postgraduate research degrees
    • PhD research disciplines and programmes
    • PhD funding opportunities and studentships
    • How to apply for your PhD
    • Research environment
    • Investing in research careers
    • Strategic plan
    • Research concordat
    • News, events, publications and films
    • Featured research and knowledge exchange projects
    • Research and knowledge exchange news
    • Inaugural lectures
    • Research and knowledge exchange publications and films
    • Academic staff search
  • About us
  • Business and employers
  • Alumni, supporters and giving
  • Current students
  • Staff
  • Accessibility
Search our site
Image of checkland building falmer campus
About us
  • About us
  • Your university
  • Governance and structure
  • Working with us
  • Statistics and legal
  • News and events
  • Contact us
  • News and events
  • News
  • 2016
  • Fighting infections with viruses

Fighting infections with viruses

Scientists at the University of Brighton have shown that viruses can kill bacteria and may be used to combat common infections related to the use of medical devices such as catheters.

9 February 2016

This new insight could lead to new methods of preventing infections and could contribute to overcoming problems with antibiotic resistance.

The news comes after the recent government review on the antibiotic resistance challenge suggested that deaths from antibiotic resistant infection could exceed deaths from cancer by 2050, and cost the global economy $100 trillion

A team led by Dr Brian Jones, Reader in Molecular and Medical Microbiology at the university’s College of Life, Health and Physical Sciences, has been studying infections associated with the use of urinary catheters which are used in their millions across the world every year.

The team has focused on a particular species of bacteria called Proteus mirabilis, which is a common cause of these infections and leads to extensive encrustation and blockage of catheters. This, in turn, leads to the onset of serious complications such as kidney infection and septicaemia, one of the UK’s biggest killers.

Dr Brian Jones

Dr Jones and his team have evaluated the potential for viruses that specifically infect and kill bacteria – called bacteriophage – to prevent these infections.

Dr Jones, currently serving as Head of Research Development at Queen Victoria Hospital in East Grinstead, West Sussex, said: “Our work provides good initial evidence that bacteriophage can treat infections caused by Proteus mirabilis and prevent catheter blockage.

“This could lead to new ways of managing patients fitted with urinary catheters, providing much benefit to a large number of patients, and also contribute to reducing antibiotic use and tackling resistance.”

Dr Jones said more research was needed: “We are still at a very early stage in this work, and have a long way to go before we can be sure this will lead to an effective way to control these infections, but bacteriophage have been used extensively in other countries for decades, and the challenge of antibiotic resistance makes it important to look at using these promising alternatives to antibiotics. We think an important issue will be in developing ways to deliver bacteriophage as needed, which is a key aim of our ongoing work."

The research is a collaboration with scientists and clinicians from the University of Brighton, the University of Bath, Queens University of Belfast, Surrey and Sussex Healthcare NHS Trust, Frontier Pathology NHS Partnership, the Blond McIndoe Research Foundation, and Queen Victoria Hospital NHS Foundation Trust.

Dr Karen Knox, Consultant Microbiologist and Lead Infection Control Doctor with Surrey & Sussex Healthcare NHS Trust and Frontier Pathology, said: “Long term indwelling urinary catheters pose significant healthcare associated infection risk and burden, often in elderly and already immunocompromised patients. 

“This research is an exciting opportunity to explore and potentially open up new avenues of infection prevention and management, which provides some optimism in the era of ever increasing antimicrobial resistance.”

Dr Toby Jenkins, Reader in Biophysical Chemistry at the University of Bath, said: “As effective antibiotics become ever scarcer, we have to look at alternatives. This study strongly suggests that a cocktail of bacteriophage is highly effective in clearing catheter associated urinary tract infection. We will engineer delivery systems over the next 12 months for the targeted delivery of such viruses where and when they are needed.”

And Professor Brendan Gilmore, from Queens University Belfast, said: “This innovative approach has the potential to provide an effective, non-antibiotic solution to catheter-associated infections which affect some of the most vulnerable patients in society. These infections have huge impact on patients and place a huge financial burden on the NHS and healthcare providers globally, so strategies to combat them are badly needed."

Back to top
  • Facebook
  • X logo
  • Instagram
  • TikTok
  • YouTube
  • LinkedIn icon

Contact us

University of Brighton
Mithras House
Lewes Road
Brighton
BN2 4AT

Main switchboard 01273 600900

Course enquiries

Sign up for updates

University contacts

Report a problem with this page

Quick links Quick links

  • Courses
  • Open days
  • Explore our prospectus
  • Academic departments
  • Academic staff
  • Professional services departments
  • Jobs
  • Privacy and cookie policy
  • Accessibility statement
  • Libraries
  • Term dates
  • Maps
  • Graduation
  • Site information
  • Online shop
  • The Student Contract

Information for Information for

  • Current students
  • International students
  • Media/press
  • Careers advisers/teachers
  • Parents/carers
  • Business/employers
  • Alumni/supporters
  • Suppliers
  • Local residents