In a separate University of Brighton project, research fellows and PhD students developed an innovative 3D-printed sensor capable of detecting TNFα, a protein that signals inflammation in the gut. Successfully tested in faecal samples, the technology could one day support simpler, non-invasive monitoring of inflammatory bowel disease and other gut conditions. The work also provides an important foundation for a wider University project developing an implantable device that could continuously monitor bowel health and deliver medication directly where it is needed.
The University's expertise has also led to collaborations with researchers across the UK and internationally. Working with the University of Strathclyde and the National Measurement Laboratory at LGC, Professor Patel contributed to the development of a 3D-printed sensor capable of detecting cardiac troponin – a protein released during a heart attack. Costing around £0.20 to produce, the device successfully detected clinically relevant levels in human serum, highlighting its potential as the basis for faster, lower-cost diagnostic tests closer to the patient.
In collaboration with the University of Naples Federico II, Dr Chloe Miller, Professor Patel and visiting researcher Dr Panagiota M. Kalligosfyri developed a fully 3D-printed sensor capable of detecting tiny biological molecules associated with diseases including lung cancer. Costing around 30 pence to produce, the device successfully detected these biomarkers in laboratory testing, laying the groundwork for faster and more accessible diagnostic tests in the future.
Professor Patel added: "Although each of these projects tackles a different health challenge, they're all built on the same idea: creating diagnostic technologies that are better for patients, better for the environment and easier for the world to use.
"Ultimately, we want to remove barriers. Whether someone is developing new diagnostics in Brighton, Birmingham or a low-resource setting on the other side of the world, our vision is that these sensors should be simple to manufacture, affordable to produce and straightforward to adapt for new diseases."
The team's long-term ambition is to create a new generation of diagnostic tools that are not only more affordable and environmentally sustainable – but can also be manufactured almost anywhere in the world.
By removing barriers around cost and production, the researchers hope their work will help bring faster, earlier diagnosis within reach of more patients and healthcare systems worldwide.
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